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Increased activity of testosterone hydroxylases in liver microsomes of diabetic rats treated with insulin

Authordc.contributor.authordel Villar, Eugenia 
Authordc.contributor.authorMancilla, Jerson 
Authordc.contributor.authorVega, Patricio 
Authordc.contributor.authorSanchez, Emilio 
Admission datedc.date.accessioned2018-12-20T15:05:08Z
Available datedc.date.available2018-12-20T15:05:08Z
Publication datedc.date.issued1985
Cita de ítemdc.identifier.citationComparative Biochemistry and Physiology -- Part B: Biochemistry and, Volumen 81, Issue 3, 2018, Pages 691-694
Identifierdc.identifier.issn03050491
Identifierdc.identifier.other10.1016/0305-0491(85)90388-8
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157682
Abstractdc.description.abstract1. 1. Liver microsomes from alloxan diabetic rats displayed decreased activity to hydroxylate testosterone only at the 2-α and 6-β positions. 2. 2. Diabetic insulin-treated rats showed higher hydroxylase activities than diabetic and control rats in the formation of all testosterone metabolites analyzed. 3. 3. The sodium dodecylsulfate electrophoretic profile of liver microsomal proteins from each group of rats exhibited distinct increases as well as decreases in the cytochrome P-450 region. 4. 4. Stimulation of testosterone metabolism by insulin may be associated with a higher synthesis of certain cytochrome P-450 isozymes. © 1985.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceComparative Biochemistry and Physiology -- Part B: Biochemistry and
Keywordsdc.subjectBiochemistry
Keywordsdc.subjectPhysiology
Keywordsdc.subjectMolecular Biology
Títulodc.titleIncreased activity of testosterone hydroxylases in liver microsomes of diabetic rats treated with insulin
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile