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Analgesic effects of intracerebroventricular administration of calcium channel blockers in mice

Authordc.contributor.authorMiranda, 
Authordc.contributor.authorPelissier, 
Authordc.contributor.authorSierralta, 
Admission datedc.date.accessioned2018-12-20T15:09:11Z
Available datedc.date.available2018-12-20T15:09:11Z
Publication datedc.date.issued1993
Cita de ítemdc.identifier.citationGeneral Pharmacology, Volumen 24, Issue 1, 2018, Pages 201-204
Identifierdc.identifier.issn03063623
Identifierdc.identifier.other10.1016/0306-3623(93)90035-V
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157965
Abstractdc.description.abstract1. 1. The antinociceptive action of calcium channel blockers administered intracerebroventricularly to mice using the acetic acid writhing test was studied. 2. 2. The drugs produced dose-dependent inhibition of the number of writhes induced by the intraperitoneal administration of 10 ml/kg of 0.6% acetic acid. 3. 3. The CaCBs may be ranked from most to least potent as follows: verapamil > nimodipine > diltiazem > flunarizine > nifedipine > cinnarizine. 4. 4. Since naloxone pretreatment was not able to inhibit the antinociception produced by CaCBs an opioid mechanism of action is excluded. 5. 5. It is suggested that CaCBs can induce analgesia through a decrease in cellular Ca2+ availability, increasing the nociceptive threshold. © 1993.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceGeneral Pharmacology
Keywordsdc.subjectPharmacology
Títulodc.titleAnalgesic effects of intracerebroventricular administration of calcium channel blockers in mice
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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