Voltammetric study of ketorolac and its differential pulse polarographic determination in pharmaceuticals
Author
dc.contributor.author
Sturm,
Author
dc.contributor.author
Canelo,
Author
dc.contributor.author
Núñez Vergara, Luis
Author
dc.contributor.author
Squella Serrano, Juan
Admission date
dc.date.accessioned
2018-12-20T15:09:18Z
Available date
dc.date.available
2018-12-20T15:09:18Z
Publication date
dc.date.issued
1997
Cita de ítem
dc.identifier.citation
Talanta, Volumen 44, Issue 5, 2018, Pages 931-937
Identifier
dc.identifier.issn
00399140
Identifier
dc.identifier.other
10.1016/S0039-9140(96)02143-1
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/158015
Abstract
dc.description.abstract
A differential pulse polarographic method for the quantitative determination of ketorolac is described. Ketorolac is an antiinflammatory-analgesic agent that is directly electroreducible at the mercury electrode. The polarographic reduction is due to the reduction of the benzoyl moiety in the ketorolac molecule. For analytical purposes, a very well resolved diffusion controlled differential pulse polarographic peak obtained at pH 9 was selected. This peak was used to develop a new method for the determination of ketorolac in pharmaceutical dosage forms. Recovery study shows that the method is sufficiently accurate and precise to be applied in the individual tablet assay of commercial samples.