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Author | dc.contributor.author | Aguirre, María C. | |
Author | dc.contributor.author | Delporte, Carla | |
Author | dc.contributor.author | Backhouse, Nadine | |
Author | dc.contributor.author | Erazo, Silvia | |
Author | dc.contributor.author | Letelier, María Eugenia | |
Author | dc.contributor.author | Cassels Niven, Bruce | |
Author | dc.contributor.author | Silva, Ximena | |
Author | dc.contributor.author | Alegría, Sergio | |
Author | dc.contributor.author | Negrete, Rosa | |
Admission date | dc.date.accessioned | 2018-12-20T15:09:55Z | |
Available date | dc.date.available | 2018-12-20T15:09:55Z | |
Publication date | dc.date.issued | 2006 | |
Cita de ítem | dc.identifier.citation | Bioorganic and Medicinal Chemistry, Volumen 14, Issue 16, 2018, Pages 5673-5677 | |
Identifier | dc.identifier.issn | 09680896 | |
Identifier | dc.identifier.other | 10.1016/j.bmc.2006.04.021 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/158061 | |
Abstract | dc.description.abstract | Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material showed that some extracts have potent anti-inflammatory activities. Further fractionation led to the isolation and identification of betulinic acid, a mixture of ursolic and oleanolic acids, and the 2α-hydroxy derivatives alphitolic, asiatic, and corosolic acids. The latter three were evaluated in vivo in the mouse ear assay for their topical anti-inflammatory activity, inducing inflammation with either arachidonic acid (AA) or 12-O-tetradecanoylphorbol-13 acetate (TPA). Only corosolic acid was active in the AA assay, with similar potency to nimesulide, but all three triterpene acids inhibited TPA-induced inflammation with potencies comparable to that of indomethacin. © 2006 Elsevier Ltd. All rights reserved. | |
Lenguage | dc.language.iso | en | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | Bioorganic and Medicinal Chemistry | |
Keywords | dc.subject | Alphitolic acid | |
Keywords | dc.subject | Anti-inflammatory activity-triterpenoids | |
Keywords | dc.subject | Asiatic acid | |
Keywords | dc.subject | Corosolic acid | |
Keywords | dc.subject | Ugni molinae | |
Título | dc.title | Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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