Trophic factors in cerebrospinal fluid and spinal cord of patients with tropical spastic paraparesis, HIV, and Creutzfeldt-Jakob disease
Author
dc.contributor.author
Albrecht, David
Author
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García Nannig, Lorena
Author
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Cartier Rovirosa, Luis
Author
dc.contributor.author
Kettlun, Ana M.
Author
dc.contributor.author
Vergara, Carmen
Author
dc.contributor.author
Collados, Lucia
Author
dc.contributor.author
Valenzuela, M. Antonieta
Admission date
dc.date.accessioned
2018-12-20T15:10:01Z
Available date
dc.date.available
2018-12-20T15:10:01Z
Publication date
dc.date.issued
2006
Cita de ítem
dc.identifier.citation
AIDS Research and Human Retroviruses, Volumen 22, Issue 3, 2018, Pages 248-254
Identifier
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08892229
Identifier
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10.1089/aid.2006.22.248
Identifier
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https://repositorio.uchile.cl/handle/2250/158105
Abstract
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HTLV-1-associated myelopathy/tropical spastic paraparesis (TSP/HAM) is a chronic CNS disease characterized by axomyelinic degeneration of the long axons of corticospinal tracts. Levels of NGF, NT-3, NT-4/5, BDNF, GDNF, CNTF, and FGF-2 were measured in the cerebrospinal fluid (CSF) of 21 TSP/HAM patients and 20 controls. NGF, BDNF, and FGF-2 levels were also determined in 19 patients with HIV motor cognitive motor syndrome, and in 21 subjects diagnosed with Creutzfeldt Jakob disease (CJD). No significant differences were detected in the concentrations of NGF, BDNF, NT-3, NT-4/5, GDNF, and CNTF in the CSF between TSP/HAM patients and controls. FGF-2 was significantly lower in the CSF of the three groups of patients compared with controls; the HIV group exhibited the lowest values. HIV patients differed from TSP/HAM in their significantly higher levels of NGF and lower levels of BDNF and FGF-2, whereas CJD patients differed only in their higher levels of NGF. Immunohistochemical studies w