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Polarogaphic and microcalorimetric study of the interaction between glutathione and amoxycillin

Authordc.contributor.authorSquella Serrano, Juan 
Authordc.contributor.authorBenavente, G. 
Authordc.contributor.authorGallo, B. 
Authordc.contributor.authorParedes, S. 
Authordc.contributor.authorNúñez Vergara, Luis 
Admission datedc.date.accessioned2018-12-20T15:10:03Z
Available datedc.date.available2018-12-20T15:10:03Z
Publication datedc.date.issued1988
Cita de ítemdc.identifier.citationBioelectrochemistry and Bioenergetics, Volumen 20, Issue 1-3, 2018, Pages 125-131
Identifierdc.identifier.issn03024598
Identifierdc.identifier.other10.1016/S0302-4598(98)80010-X
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158117
Abstractdc.description.abstractThe enthalpies of the reaction between glutathione and amoxycillin have been measured directly using a flow microcalorimeter. Comparative results are obtained by using an ac polarographic method previously developed in our laboratories. The results obtained imply that glutathione reacts with amoxycillin spontaneously and that this process is exothermic at physiological pH and temperature. Evidence of this interaction is very important in order to permit the postulation of a new biotransformation route for amoxycillin. Furthermore, the comparable results of two very different methods strongly support our previous statement that polarography is a very important tool for the study of interactions of biological significance. © 1988.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBioelectrochemistry and Bioenergetics
Keywordsdc.subjectBiophysics
Keywordsdc.subjectPhysical and Theoretical Chemistry
Keywordsdc.subjectElectrochemistry
Títulodc.titlePolarogaphic and microcalorimetric study of the interaction between glutathione and amoxycillin
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile