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Conjugation of Kahalalide F with gold nanoparticles to enhance in vitro antitumoral activity

Authordc.contributor.authorHosta, Leticia 
Authordc.contributor.authorPla-Roca, Mateu 
Authordc.contributor.authorArbiol, Jordi 
Authordc.contributor.authorLópez Iglesias, Carmen 
Authordc.contributor.authorSamitier, Josep 
Authordc.contributor.authorCruz, Luis 
Authordc.contributor.authorKogan Bocian, Marcelo 
Authordc.contributor.authorAlbericio, Fernando 
Admission datedc.date.accessioned2018-12-20T15:10:06Z
Available datedc.date.available2018-12-20T15:10:06Z
Publication datedc.date.issued2009
Cita de ítemdc.identifier.citationBioconjugate Chemistry, Volumen 20, Issue 1, 2009, Pages 138-146
Identifierdc.identifier.issn10431802
Identifierdc.identifier.other10.1021/bc800362j
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158144
Abstractdc.description.abstractTwo Cys-containing analogues of the anticancer drug Kahalalide F are synthesized and conjugated to 20 and 40 nm gold nanoparticles (GNPs). The resulting complexes are characterized by different analytical techniques to confirm the attachment of peptide to the GNPs. The self-assembly capacity of a peptide dramatically influences the final ratio number of molecules per nanoparticle, saturating the nanoparticle surface and prompting multilayered capping on the surface. In such way, the nanoparticle could act as a concentrator for the delivery of drugs, thereby increasing bioactivity. The GNP sizes and the conjugation have influence on the biological activities. Kahalalide F analogues conjugated with GNPs are located subcellularly at lysosome-like bodies, which may be related to the action mechanism of Kahalalide F. The results suggest that the selective delivery and activity of Kahalalide F analogues can be improved by conjugating the peptides to GNPs.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBioconjugate Chemistry
Keywordsdc.subjectBiotechnology
Keywordsdc.subjectBioengineering
Keywordsdc.subjectBiomedical engineering
Keywordsdc.subjectPharmacology
Keywordsdc.subjectPharmaceutical science
Keywordsdc.subjectOrganic chemistry
Títulodc.titleConjugation of Kahalalide F with gold nanoparticles to enhance in vitro antitumoral activity
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorrvh
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile