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Spectroscopic characterization of the inclusion complexes of luteolin with native and derivatized β-cyclodextrin

Authordc.contributor.authorJullian Matthaei, Carolina 
Authordc.contributor.authorCifuentes, Constanza 
Authordc.contributor.authorAlfaro, Muriel 
Authordc.contributor.authorMiranda, Sebastián 
Authordc.contributor.authorBarriga, Germán 
Authordc.contributor.authorOlea Azar, Claudio 
Admission datedc.date.accessioned2018-12-20T15:10:26Z
Available datedc.date.available2018-12-20T15:10:26Z
Publication datedc.date.issued2010
Cita de ítemdc.identifier.citationBioorganic and Medicinal Chemistry, Volumen 18, Issue 14, 2018, Pages 5025-5031
Identifierdc.identifier.issn09680896
Identifierdc.identifier.other10.1016/j.bmc.2010.05.079
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158179
Abstractdc.description.abstractThe inclusion complexes of Luteolin (LU) with cyclodextrins (CDs) including β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) and dimethyl-β-cyclodextrin (DMβCD), Scheme 1, have been investigated using the method of steady-state fluorescence. The stoichiometric ratio of the three complexes was found to be 1:1 and the stability constants (K) were estimated from spectrofluorometric titrations, as well as the thermodynamic parameters. Maximum inclusion ability was obtained in the case of HPβCD followed by DMβCD and βCD. Moreover, 1H NMR and 2D NMR were carried out, revealing that LU has different form of inclusion which is in agreement with molecular modeling studies. These models confirm that when LU-βCD and LU-DMβCD complexes are formed, the B-ring is oriented toward the primary rim; however, for LU-HPβCD complex this ring is oriented toward the secondary rim. The ESR results showed that the antioxidant activity of luteolin was the order LU-HPβCD > LU-DMβCD > LU-βCD > LU, hence
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBioorganic and Medicinal Chemistry
Keywordsdc.subjectCyclodextrins
Keywordsdc.subjectDocking
Keywordsdc.subjectDPPH
Keywordsdc.subjectESR
Keywordsdc.subjectLuteolin
Keywordsdc.subjectROESY
Keywordsdc.subjectThermodynamic study
Títulodc.titleSpectroscopic characterization of the inclusion complexes of luteolin with native and derivatized β-cyclodextrin
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile