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Lipid nanoparticles for the topical delivery of retinoids and derivatives

Authordc.contributor.authorMorales, Javier O. 
Authordc.contributor.authorValdés, Karina 
Authordc.contributor.authorMorales, Javier O. 
Authordc.contributor.authorOyarzún Ampuero, Felipe 
Admission datedc.date.accessioned2018-12-20T15:11:00Z
Available datedc.date.available2018-12-20T15:11:00Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationNanomedicine, Volumen 10, Issue 2, 2018, Pages 253-269
Identifierdc.identifier.issn17486963
Identifierdc.identifier.issn17435889
Identifierdc.identifier.other10.2217/nnm.14.159
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158350
Abstractdc.description.abstract© 2015 Future Medicine Ltd.Retinoids are lipophilic compounds that are highly used in cosmetics/therapeutics for skin disorders. Conventional formulations are limited by poor water solubility, high chemical/photochemical instability and the irritation of retinoids. Interestingly, lipid nanoparticles enable the administration of retinoids in aqueous media, providing drug stabilization and controlled release. Recently, it has been demonstrated that retinoids in solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions and nanocapsules can decrease degradation, improve targeting and enhance efficacy for the treatment of skin disorders. This article focuses on the formulation, fabrication, characterization and in vitro/in vivo evaluation of solid lipid nanoparticles, nanostructured lipid carriers, nanoemulsions and nanocapsules loaded with retinoids for skin administration. Furthermore, the incorporation of these lipid nanoparticles into secondary vehicles is discussed.
Lenguagedc.language.isoen
Publisherdc.publisherFuture Medicine Ltd.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceNanomedicine
Keywordsdc.subjecthydrogels
Keywordsdc.subjectlipid nanosystems
Keywordsdc.subjectnanocapsules
Keywordsdc.subjectnanoemulsions
Keywordsdc.subjectnanostructured lipid carriers
Keywordsdc.subjectretinoids
Keywordsdc.subjectskin delivery
Keywordsdc.subjectsolid lipid nanoparticles
Keywordsdc.subjecttopical delivery
Títulodc.titleLipid nanoparticles for the topical delivery of retinoids and derivatives
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile