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Radioprotection (UV- and gamma-rays) of DNA molecule by indole and indole-derivatives

Authordc.contributor.authorTomicic, I. 
Authordc.contributor.authorPieber, M. 
Authordc.contributor.authorRomero, C. 
Authordc.contributor.authorSoto, A. 
Authordc.contributor.authorTohá, J. C. 
Cita de ítemdc.identifier.citationZeitschrift fur Naturforschung - Section C Journal of Biosciences, Volumen 28, Issue 7-8, 2018, Pages 379-384
Abstractdc.description.abstractThe radioprotective ability of L-tryptophan, tryptamine, 3-indoleacetic and indole (10−4 m), on UV and gamma irradiated DNA (10−4 m) is studied. UV radioprotection is accomplished in the following order of efficiency: L-Tryptophan and 3-indoleacetic acid > indole and tryptamine. The corresponding DRF measured as absorbancy loss at 260 nm, were: L-Tryptophan and 3-indoleacetic acid around 3 and tryptamine and indole around 1. When absorbancy loss plus changes in the patterns of the absorbancy curve were considered the DRF was: L-Tryptophan 2.53, 3-indoleacetic acid 1.54, indole 1.22 and tryptamine 0.75, respectively. For gamma radiation damage the order of radioprotection found was: Indole, L-tryptophan and tryptamine > 3-indoleacetic acid. The DRF when compairing the absorbancy loss at 260 nm, were: L-Tryptophan, Indole and tryptamine around 11 and 3-indoleacetic Acid around 4. When evaluating total changes in absorbancy the DRF were: Indole and L-tryptophan around 6.5, tryptamine 3.7
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceZeitschrift fur Naturforschung - Section C Journal of Biosciences
Keywordsdc.subjectDNA radioprotection
Keywordsdc.subjectradioprotective action
Títulodc.titleRadioprotection (UV- and gamma-rays) of DNA molecule by indole and indole-derivatives
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile