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Bioactive phenolic derivatives from Acaena splendens methanol extract

Authordc.contributor.authorBackhouse, N. 
Authordc.contributor.authorDelporte, C. 
Authordc.contributor.authorNegrete, R. 
Authordc.contributor.authorSan Feliciano, S. A. 
Authordc.contributor.authorLópez Pérez, J. L. 
Admission datedc.date.accessioned2018-12-20T15:20:33Z
Available datedc.date.available2018-12-20T15:20:33Z
Publication datedc.date.issued2002
Cita de ítemdc.identifier.citationPhytotherapy Research, Volumen 16, Issue 6, 2018, Pages 562-566
Identifierdc.identifier.issn0951418X
Identifierdc.identifier.other10.1002/ptr.997
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158818
Abstractdc.description.abstractAcaena splendens H. et A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the in vivo reduction of bacterial pyrogen-induced fever in rabbits and carrageenan-induced paw oedema in guinea pigs is presented. The methanol extract named ME-1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassay-guided fractionation by column chromatography afforded the active fraction, which contained (-,-)-epicatechin, tiliroside, 7-O-acetyl-3-O-Β-D-glucosyl-kaempferol and 7-Β-D-glucosyloxy-5-hydroxy-chromone. Copyright © 2002 John Wiley & Sons, Ltd.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePhytotherapy Research
Keywordsdc.subjectAcaena splendens
Keywordsdc.subjectAntiinflammatory
Keywordsdc.subjectAntipyretic activities
Keywordsdc.subjectChromone
Keywordsdc.subjectFlavonoids
Títulodc.titleBioactive phenolic derivatives from Acaena splendens methanol extract
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile