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Differential pulse polarographic and UV-vis spectrophotometric study of inclusion complexes formed by 1,4-dihydropyridine calcium antagonists, nifedipine and nicardipine with β-cyclodextrin

Authordc.contributor.authorYáñez, C. 
Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorSquella Serrano, Juan 
Admission datedc.date.accessioned2018-12-20T15:20:41Z
Available datedc.date.available2018-12-20T15:20:41Z
Publication datedc.date.issued2003
Cita de ítemdc.identifier.citationElectroanalysis, Volumen 15, Issue 22, 2003, Pages 1771-1777
Identifierdc.identifier.issn10400397
Identifierdc.identifier.other10.1002/elan.200302720
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158866
Abstractdc.description.abstractThe formation of inclusion complexes of well-known 1,4-dihydropyridine calcium antagonists, such as nifedipine (NF) and nicardipine (NC), with beta-cyclodextrin (betaCD) was investigated by differential pulse polarography (DPP) and UV-vis spectrophotometry. The equimolar variation method indicated the formation of the NF-betaCD (1:1, M:M) and a NC-betaCD (1:1, M:M) inclusion complexes. Titrations using the DPP peak currents for NF and NC permitted one to determine formation constant values of (135 +/- 20) M-1 and (357 41) M-1 for NF-betaCD and NC-betaCD, respectively. For comparative purposes we have also applied phase solubility studies with spectrophotometric detection obtaining formation constant values of (129 +/- 5) M-1 and (385 +/- 19) M-1 for NF-betaCD and NC-betaCD, respectively. According to the DPP studies, we can postulate that the inclusion moiety were the nitroaromatic group, in the case of NF-betaCD, and the phenyl group on 3-position of the 1,4-DHP, in the case of NC-betaCD. The solubility of NF in water was increased about three times due to the formation of an inclusion complex with betaCD. For NC the solubility was increased almost seven times.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceElectroanalysis
Keywordsdc.subjectβ-Cyclodextrin
Keywordsdc.subjectDifferential pulse polarography
Keywordsdc.subjectInclusion complexes
Keywordsdc.subjectNicardipine
Keywordsdc.subjectNifedipine
Títulodc.titleDifferential pulse polarographic and UV-vis spectrophotometric study of inclusion complexes formed by 1,4-dihydropyridine calcium antagonists, nifedipine and nicardipine with β-cyclodextrin
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorrvh
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile