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Antiinflammatory and antipyretic metabolites of Acaena splendens

Authordc.contributor.authorBackhouse, N. 
Authordc.contributor.authorDelporte, C. 
Authordc.contributor.authorNegrete, R. 
Authordc.contributor.authorSuárez, S. 
Authordc.contributor.authorCassels Niven, Bruce 
Authordc.contributor.authorBreitmaier, E. 
Authordc.contributor.authorSchneider, C. 
Admission datedc.date.accessioned2018-12-20T15:20:44Z
Available datedc.date.available2018-12-20T15:20:44Z
Publication datedc.date.issued1997
Cita de ítemdc.identifier.citationPharmaceutical Biology, Volumen 35, Issue 1, 2018, Pages 49-54
Identifierdc.identifier.issn13880209
Identifierdc.identifier.other10.1076/phbi.35.1.49.13273
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/158889
Abstractdc.description.abstractAcaena splendens H. et A., Rosaceae, has been used in Chilean traditional medicine for the treatment of fever and inflammation. The antipyretic and antiinflammatory properties of the infusion, methanol, petroleum ether and dichloromethane extracts of the whole plant were examined. A description and results of the in vivo studies are presented, based on the reduction of bacterial pyrogen-induced fever in rabbits and carrageenan-induced paw edema in guinea pigs, as well as acute toxicity assays of the methanol extracts in mice. The acqueous, methanol and dichloromethane extracts showed marked antipyretic and antiinflammatory activities; the dichloromethane extract being the most active in both assays. The petroleum ether was subjected to bioassay-guided fractionation by column chromatography, yielding an active fraction containing a mixture of triterpenes in which β-amyrin was identified as a major component and lupeol was also present. Similarly, the dichloromethane extract yielded olea
Lenguagedc.language.isoen
Publisherdc.publisherSwets en Zeitlinger B.V.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePharmaceutical Biology
Keywordsdc.subjectAcaena splendens
Keywordsdc.subjectAntiinflammatory
Keywordsdc.subjectAntipyretic activities
Keywordsdc.subjectPentacyclic triterpenes
Keywordsdc.subjectRosaceae
Keywordsdc.subjectSteroids
Títulodc.titleAntiinflammatory and antipyretic metabolites of Acaena splendens
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile