Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor
Author
dc.contributor.author
Salgado, Francisco
Author
dc.contributor.author
Caballero, Julio
Author
dc.contributor.author
Vargas, Reinaldo
Author
dc.contributor.author
Cornejo, Alberto
Author
dc.contributor.author
Areche, Carlos
Admission date
dc.date.accessioned
2020-05-05T23:56:26Z
Available date
dc.date.available
2020-05-05T23:56:26Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Natural Product Research 2020, Vol. 34, No. 5, 646–650
es_ES
Identifier
dc.identifier.other
10.1080/14786419.2018.1492576
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/174423
Abstract
dc.description.abstract
Alzheimer s disease (AD) is the most common form of dementia involving Ab and tau protein. So far, AD cure remains elusive, but considering
that AD progresses throughout tau pathology, which turns tau protein
an appropriate target, besides tau is also included in other neurodegenerative disorders named as tauopathies. Here, we have isolated seventeen compounds belonging to six lichens species. Due to scarce of
spectroscopic data of the compound 5,7-dihydroxy-6-methylphthalide,
we explained their structural elucidation based on NMR data. In this
study, we show that only tenuiorin from Umbilicaria antarctica inhibited
50% of tau 4R at 100mM. Then, we shown that molecular interactions
of tenuiorin with the steric zipper model of the hexapeptide
306VQIVYK311 were studied by docking calculations and the results suggested that tenuiorin forms both hydrogen bonds with lysine and glutamine side chains and forms several hydrophobic interactions with
valine and lysine from 306VQIVYK311 motif.
Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
1150745
INACH
RT 13-13
MT 03-14
Fondo Nacional de Desarrollo Cientifico and Tecnologico
Continental and Antarctic Lichens: isolation, identification and molecular modeling of the depside tenuiorin from the Antarctic lichen Umbilicaria antarctica as tau protein inhibitor