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Authordc.contributor.authorCourt, Angela C. 
Authordc.contributor.authorLe-Gatt, Alice 
Authordc.contributor.authorLuz-Crawford, Patricia 
Authordc.contributor.authorParra, Eliseo 
Authordc.contributor.authorAliaga Tobar, Víctor 
Authordc.contributor.authorBatiz, Luis Federico 
Authordc.contributor.authorContreras, Rafael A. 
Authordc.contributor.authorOrtúzar, María Ignacia 
Authordc.contributor.authorKurte, Mónica 
Authordc.contributor.authorElizondo Vega, Roberto 
Authordc.contributor.authorMaracajá Coutinho, Vinicius 
Authordc.contributor.authorPino Lagos, Karina 
Authordc.contributor.authorFigueroa, Fernando E. 
Authordc.contributor.authorKhoury, Maroun 
Admission datedc.date.accessioned2020-05-08T12:36:26Z
Available datedc.date.available2020-05-08T12:36:26Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationEMBO reports Vol. 21 No. 2 Feb 2020es_ES
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/174556
Abstractdc.description.abstractMesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune-mediated diseases. They exert immunoregulatory and tissue-restoring effects. MSC-mediated transfer of mitochondria (MitoT) has been demonstrated to rescue target organs from tissue damage, yet the mechanism remains to be fully resolved. Therefore, we explored the effect of MitoT on lymphoid cells. Here, we describe dose-dependent MitoT from mitochondria-labeled MSCs mainly to CD4(+) T cells, rather than CD8(+) T cells or CD19(+) B cells. Artificial transfer of isolated MSC-derived mitochondria increases the expression of mRNA transcripts involved in T-cell activation and T regulatory cell differentiation including FOXP3, IL2RA, CTLA4, and TGF beta 1, leading to an increase in a highly suppressive CD25(+)FoxP3(+) population. In a GVHD mouse model, transplantation of MitoT-induced human T cells leads to significant improvement in survival and reduction in tissue damage and organ T CD4(+), CD8(+), and IFN-gamma(+) expressing cell infiltration. These findings point to a unique CD4(+) T-cell reprogramming mechanism with pre-clinical proof-of-concept data that pave the way for the exploration of organelle-based therapies in immune diseases.es_ES
Patrocinadordc.description.sponsorshipNational Agency for Investigation and Development: ANID (Agencia Nacional de Investigacion y Desarrollo) 1170852 15130011 PAI79170021es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherWileyes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceEMBO reportses_ES
Keywordsdc.subjectGraft-versus-host diseasees_ES
Keywordsdc.subjectImmunosuppressiones_ES
Keywordsdc.subjectMesenchymal stem cellses_ES
Keywordsdc.subjectMitochondrial transferes_ES
Keywordsdc.subjectT regulatory cellses_ES
Títulodc.titleMitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory responsees_ES
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorcrbes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile