Fatty acid and lipid metabolism in liver of pregnant mice and their offspring is influenced by unbalanced folates/vitamin B12 diets
Author
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Castaño Moreno, Erika
Author
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Castillo, Valeska
Author
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Peñailillo, Reyna
Author
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Llanos Silva, Miguel
Author
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Valenzuela Báez, Rodrigo
Author
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Ronco Macchiavello, Ana
Admission date
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2020-05-19T15:54:20Z
Available date
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2020-05-19T15:54:20Z
Publication date
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2020
Cita de ítem
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Prostaglandins, Leukotrienes and Essential Fatty Acids 154 (2020) 102057
es_ES
Identifier
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10.1016/j.plefa.2020.102057
Identifier
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https://repositorio.uchile.cl/handle/2250/174829
Abstract
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Micronutrients (folates and vitamin B12) and long chain polyunsaturated fatty acids (LC-PUFAs) are linked through the one carbon cycle. We studied the effects of pre and postnatal high FA/low B12 diets (HFLB12) on hepatic fatty acid metabolism. Pregnant C57BL/6 mice were divided in two groups: control (2 mg folic acid: FA/25 mu g vitamin B12/Kg food) and HFLB12 diets (8 mg FA/5 mu g vitamin B12/Kg food). Offspring continued on the same diets until 60 days old. We determined hepatic fatty acid profile in dams and offspring and the expression of PPARa, Cpt-1, Acox-1 and Fas and the enzymatic activity of desaturases, all involved in lipid metabolism. In liver of dams, the HFHB12 diet decreased total fatty acids and desaturase activities; in offspring, effects were opposite, being more noticeable in females. Prenatal and postnatal unbalanced folic acid/B12 diets play a crucial role in regulating genes and enzymes involved in lipid metabolism in liver of dams and their offspring in adulthood.
es_ES
Patrocinador
dc.description.sponsorship
Comisión Nacional de Investigación Científica y Tecnológica (CONICYT), CONICYT FONDECYT: 1130188, 11140174.
Grant Abraham Stekel 2016.
CONICYT-PCHA/Doctorado Nacional 2017-21170259.