Metabolomic profiling of left ventricular diastolic dysfunction in women with or at risk for HIV infection: The women’s interagency HIV study
Author
dc.contributor.author
Bravo, Claudio A.
Author
dc.contributor.author
Hua, Simin
Author
dc.contributor.author
Deik, Amy
Author
dc.contributor.author
Lazar, Jason
Author
dc.contributor.author
Hanna, David B.
Author
dc.contributor.author
Scott, Justin
Author
dc.contributor.author
Chai, Jin Choul
Author
dc.contributor.author
Kaplan, Robert C.
Author
dc.contributor.author
Anastos, Kathryn
Author
dc.contributor.author
Robles, Octavio A.
Author
dc.contributor.author
Clish, Clary B.
Author
dc.contributor.author
Kizer, Jorge R.
Author
dc.contributor.author
Qi, Qibin
Admission date
dc.date.accessioned
2020-05-25T14:01:01Z
Available date
dc.date.available
2020-05-25T14:01:01Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
J Am Heart Assoc. (2020)18; 9(4): e013522
es_ES
Identifier
dc.identifier.other
10.1161/JAHA.119.013522
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/174928
Abstract
dc.description.abstract
Background-—People living with HIV have an increased risk of left ventricular diastolic dysfunction (LVDD) and heart failure. HIVassociated
LVDD may reflect both cardiomyocyte and systemic metabolic derangements, but the underlying pathways remain unclear.
Methods and Results-—To explore such pathways, we conducted a pilot study in the Bronx and Brooklyn sites of the WIHS
(Women’s Interagency HIV Study) who participated in concurrent, but separate, metabolomics and echocardiographic ancillary
studies. Liquid chromatography tandem mass spectrometry–based metabolomic profiling was performed on plasma samples from
125 HIV-infected (43 with LVDD) and 35 HIV-uninfected women (9 with LVDD). Partial least squares discriminant analysis identified
polar metabolites and lipids in the glycerophospholipid-metabolism and fatty-acid-oxidation pathways associated with LVDD. After
multivariable adjustment, LVDD was significantly associated with higher concentrations of diacylglycerol 30:0 (odds ratio [OR],
1.60, 95% CI [1.01–2.55]); triacylglycerols 46:0 (OR 1.60 [1.04–2.48]), 48:0 (OR 1.63 [1.04–2.54]), 48:1 (OR 1.62 [1.01–2.60]),
and 50:0 (OR 1.61 [1.02–2.53]); acylcarnitine C7 (OR 1.88 [1.21–2.92]), C9 (OR 1.99 [1.27–3.13]), and C16 (OR 1.80 [1.13–2.87]);
as well as lower concentrations of phosphocholine (OR 0.59 [0.38–0.91]). There was no evidence of effect modification of these
relationships by HIV status.
Conclusions-—In this pilot study, women with or at risk of HIV with LVDD showed alterations in plasma metabolites in the
glycerophospholipid-metabolism and fatty-acid-oxidation pathways. Although these findings require replication, they suggest that
improved understanding of metabolic perturbations and their potential modification could offer new approaches to prevent cardiac
dysfunction in this high-risk group.
es_ES
Patrocinador
dc.description.sponsorship
United States Department of Health & Human Services National Institutes of Health (NIH) - USA
NIH National Heart Lung & Blood Institute (NHLBI) K01HL129892 R01HL140976 R01 HL132794 R01HL083760
R01HL09 5140 K01HL137557 K24 HL135413 R01 HL126543
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Allergy & Infectious Diseases (NIAID)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Cancer Institute (NCI)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute on Drug Abuse (NIDA)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Mental Health (NIMH)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Dental & Craniofacial Research (NIDCR)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH Office of Research on Women's Health (ORWH)
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Center for Advancing Translational Sciences (NCATS) UL1-TR000004
United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Center for Advancing Translational Sciences (NCATS) UL1TR000454
UNC CFAR P30-AI-050410
UAB CFAR P30-AI-027767 U01-AI-103401 U01-AI-103408 U01-AI-035004 U01AI-031834 U01-AI-034993 U01-AI-034994 U01-AI-103397 U01-AI103390 U01-AI-034989 U01-AI-042590 U01-HD-032632