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Authordc.contributor.authorReid, Brie M. 
Authordc.contributor.authorDoom, Jenalee R. 
Authordc.contributor.authorBurrows Argote, Raquel 
Authordc.contributor.authorCorrea Burrows, Paulina 
Authordc.contributor.authorLozoff, Betsy 
Authordc.contributor.authorBlanco, Estela 
Authordc.contributor.authorGahagan, Sheila 
Admission datedc.date.accessioned2020-06-03T20:06:28Z
Available datedc.date.available2020-06-03T20:06:28Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationBrain, Behavior, and Immunity. 86: (2020).4–13es_ES
Identifierdc.identifier.other10.1016/j.bbi.2019.06.003
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/175214
Abstractdc.description.abstractEarly adversity, depression, and obesity are associated with increases in low-grade inflammation. However, there are few prospective and longitudinal studies to elucidate how these associations unfold in children. The present study used latent growth curve models to examine pathways between family adversity in infancy, depressive symptoms in childhood, body mass index (BMI) in childhood, and inflammation in adolescence (age = 16-18). The study is an adolescent follow-up of infants from working-class communities around Santiago, Chile, who participated in a preventive trial of iron supplementation at 6 months of age. Anthropometrics, stressful life events, maternal depression, socioeconomic status, and developmental assessments were measured at 12 months, 5 years, 10 years, and adolescence. In adolescence, participants provided blood samples for high-sensitivity C-reactive protein (hsCRP) assessment. Greater exposure to early adversity in the form of interpersonal conflict stress in infancy indirectly associated with increased hsCRP through its association to increased intercept and slope of childhood BMI. Depressive symptoms at any time were not directly or indirectly associated with increased hsCRP. These findings contribute to our understanding of how early family adversity and its associations with obesity and depressive symptoms across childhood are linked to low-grade, chronic inflammation in adolescence. The model identified as best capturing the data supported the pivotal role of childhood BMI in explaining how early-life adversity is associated with inflammation in adolescence.es_ES
Patrocinadordc.description.sponsorshipNational Science Foundation (NSF) 00039202 F32HD088029 R01HD14122 R01HD33487 R01HL088530 T32DK071212es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceBrain, Behavior, and Immunityes_ES
Keywordsdc.subjectInflammationes_ES
Keywordsdc.subjectEarly adversityes_ES
Keywordsdc.subjectPsychosocial stresses_ES
Keywordsdc.subjectFinancial stresses_ES
Keywordsdc.subjectAdolescencees_ES
Keywordsdc.subjecthsCRPes_ES
Keywordsdc.subjectBMIes_ES
Keywordsdc.subjectDepressiones_ES
Keywordsdc.subjectGrowth curve modeles_ES
Títulodc.titlePathways to inflammation in adolescence through early adversity, childhood depressive symptoms, and body mass index: A prospective longitudinal study of Chilean infantses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorctces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile