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Authordc.contributor.authorJara Moreno, Daniela 
Authordc.contributor.authorRiveros Salvatierra, Ana L. 
Authordc.contributor.authorBarriga G., Andrés 
Authordc.contributor.authorKogan, Marcelo J. 
Authordc.contributor.authorDelporte Vergara, Carla 
Admission datedc.date.accessioned2020-06-15T23:20:37Z
Available datedc.date.available2020-06-15T23:20:37Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationCurr Pharm Des 2020;26(12):1365-1376es_ES
Identifierdc.identifier.other10.2174/1381612826666200113160840
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/175503
Abstractdc.description.abstractThe beta-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic structures that have been implicated as potential etiological factors of Alzheimer's Disease. The aim of this study was to evaluate the inhibition of beta-amyloid aggregation of ethyl acetate and ethanolic extracts obtained from Ugni molinae leaves on neurotoxic actions of beta-amyloid aggregates. Chemical analyses were carried out with the extracts in order to determine their phenolic profile and its quantification. Both extracts showed a tendency to reduce neuronal deaths caused by beta-amyloid. This tendency was inversely proportional to the evaluated concentrations. Moreover, the effect of EAE and ETE on beta-amyloid aggregation was studied by fluorimetric T Thioflavin assay and transmission electronic microscopy (TEM); the extracts showed a modulation in the aggregation process. Partly, it is believed that these effects can be attributed to the polyphenolic compounds present in the extracts.es_ES
Patrocinadordc.description.sponsorshipComisión Nacional de Investigación Cientifica y Tecnológica (CONICYT) 21130380 Comisión Nacional de Investigación Cientifica y Tecnológica (CONICYT) CONICYT FONDECYT 1130155 1170929 Comisión Nacional de Investigación Cientifica y Tecnológica (CONICYT) CONICYT FONDAP 15130011 Fondequip, Chile EQM170111es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherBentham Science Publisherses_ES
Sourcedc.sourceCurrent Pharmaceutical Designes_ES
Keywordsdc.subjectUgni molinaees_ES
Keywordsdc.subjectBeta-amyloid aggregationes_ES
Keywordsdc.subjectT Thioflavines_ES
Keywordsdc.subjectPolyphenolses_ES
Keywordsdc.subjectBeta-amyloid disaggregationes_ES
Keywordsdc.subjectFluorimetrices_ES
Títulodc.titleInhibition of beta-amyloid Aggregation of Ugni molinae Extractses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorctces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES
Access notedct.AccessRightsSin acceso a texto completoes_ES


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