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Authordc.contributor.authorBravo Sagua, Roberto 
Authordc.contributor.authorParra Ortiz, Valentina 
Authordc.contributor.authorMuñoz Córdova, Felipe 
Authordc.contributor.authorSánchez Aguilera, Pablo 
Authordc.contributor.authorGarrido, Valeria 
Authordc.contributor.authorContreras Ferrat, Ariel 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorLavandero González, Sergio 
Admission datedc.date.accessioned2020-06-17T23:01:36Z
Available datedc.date.available2020-06-17T23:01:36Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationInt Rev Cell Mol Biol 2020;350:197-264es_ES
Identifierdc.identifier.other10.1016/bs.ircmb.2019.12.007
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/175553
Abstractdc.description.abstractThe sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular space. In the case of muscle cells, calcium released from the sarco/endoplasmic reticulum in the vicinity of the contractile machinery induces cell contraction. Furthermore, sarco/endoplasmic reticulum-derived calcium also regulates gene transcription in the nucleus, energy metabolism in mitochondria and cytosolic signaling pathways. These diverse and overlapping processes require a highly complex fine-tuning that the sarco/endoplasmic reticulum provides by means of its numerous tubules and cisternae, specialized domains and contacts with other organelles. The sarco/endoplasmic reticulum also possesses a rich calcium-handling machinery, functionally coupled to both contraction-inducing stimuli and the contractile apparatus. Such is the importance of the sarco/endoplasmic reticulum for muscle cell physiology, that alterations in its structure, function or its calcium-handling machinery are intimately associated with the development of cardiometabolic diseases. Cardiac hypertrophy, insulin resistance and arterial hypertension are age-related pathologies with a common mechanism at the muscle cell level: the accumulation of damaged proteins at the sarco/endoplasmic reticulum induces a stress response condition termed endoplasmic reticulum stress, which impairs proper organelle function, ultimately leading to pathogenesis.es_ES
Patrocinadordc.description.sponsorshipComisión Nacional de Investigación Cientifica y Tecnológica (CONICYT) FONDAP 15130011 FONDECYT 1190743 1161156 1200490 Programa de Investigación Asociativa (PIA)-CONICYT 172066 Installation Program 77170004 2017 University of Chile FIDA/ABCvital 02-2018 U-Inicia UI-006-19 U-Redes Generacion VID G_2018-35 International Centre for Genetic Engineering and Biotechnology (ICGEB) CRP/CHL18-04es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceInternational Review of Cell and Molecular Biologyes_ES
Keywordsdc.subjectVascular smooth-musclees_ES
Keywordsdc.subjectHuman skeletal-musclees_ES
Keywordsdc.subjectInositol 1,4,5-trisphosphate receptorses_ES
Keywordsdc.subjectPressure-overload hypertrophyes_ES
Keywordsdc.subjectInduced cardiac-hypertrophyes_ES
Keywordsdc.subjectInduced insulin-resistancees_ES
Keywordsdc.subjectProtein-kinase-iies_ES
Keywordsdc.subjectEndoplasmic-reticulumes_ES
Keywordsdc.subjectRyanodine receptorses_ES
Keywordsdc.subjectGene-expressiones_ES
Títulodc.titleSarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and diseasees_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorctces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile