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Authordc.contributor.authorArriagada, Francisco 
Authordc.contributor.authorGunther Sapunar, Germán 
Authordc.contributor.authorMorales Valenzuela, Javier 
Admission datedc.date.accessioned2020-06-22T20:32:55Z
Available datedc.date.available2020-06-22T20:32:55Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationPharmaceutics 2020, 12, 302es_ES
Identifierdc.identifier.other10.3390/pharmaceutics12040302
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/175626
Abstractdc.description.abstractNanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent properties for application in biological systems; however, there are still several challenges related to the development of more effective and biocompatible materials. An interesting approach to enhance these nanomaterials has been the development of nanoantioxidant carriers. In this work, a hybrid nanoantioxidant carrier based on porous silica nanoplatform with rosmarinic acid antioxidant immobilized on its surface were developed and characterized. Techniques such as dynamic light scattering (DLS), zeta potential, transmission electron microscopy (TEM), N-2 adsorption-desorption measurements, differential scanning calorimetry (DSC), Fourier transform-infrared spectroscopy (FT-IR), and 2,2-diphenyl-1-picrylhydrazyl (DPPH.) assay were used to characterize and evaluate the antioxidant activity of nanocarriers. In addition, drug release profile was evaluated using two biorelevant media. The antioxidant activity of rosmarinic acid was maintained, suggesting the correct disposition of the moiety. Kinetic studies reveal that more morin is released in the simulated intestinal fluid than in the gastric one, while an anomalous non-Fickian release mechanism was observed. These results suggest a promising antioxidant nanocarrier suitable for future application in drug delivery.es_ES
Patrocinadordc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT 21160932 FONDECYT 1160757 Universidad de Chile-PII2019es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherMDPIes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourcePharmaceuticses_ES
Keywordsdc.subjectDrug deliveryes_ES
Keywordsdc.subjectFlavonoides_ES
Keywordsdc.subjectSilica nanoparticleses_ES
Keywordsdc.subjectNanocarrieres_ES
Keywordsdc.subjectNanoantioxidantes_ES
Keywordsdc.subjectMorines_ES
Keywordsdc.subjectRosmarinic acides_ES
Títulodc.titleNanoantioxidant–Based silica particles as flavonoid carrier for drug delivery applicationses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorapces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile