Role of interleukin-6 in vascular health and disease
Author
dc.contributor.author
Villar Fincheira, Paulina
Author
dc.contributor.author
Sanhueza Olivares, Fernanda
Author
dc.contributor.author
Norambuena Soto, Ignacio
Author
dc.contributor.author
Cancino Arenas, Nicole
Author
dc.contributor.author
Hernández Vargas, Felipe
Author
dc.contributor.author
Troncoso Cotal, Rodrigo
Author
dc.contributor.author
Gabrielli, Luigi
Author
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Chiong Lay, Mario
Admission date
dc.date.accessioned
2021-09-24T16:29:31Z
Available date
dc.date.available
2021-09-24T16:29:31Z
Publication date
dc.date.issued
2021
Cita de ítem
dc.identifier.citation
Frontiers in Molecular Biosciences March 2021 Volume 8 Article 641734
es_ES
Identifier
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10.3389/fmolb.2021.641734
Identifier
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https://repositorio.uchile.cl/handle/2250/182111
Abstract
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IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or
infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune
responses. IL-6 is released in the innate immune response by leukocytes as well as stromal
cells upon pattern recognition receptor activation. IL-6 then recruits immune cells and
triggers B and T cell response. Dysregulated IL-6 activity is associated with pathologies
involving chronic inflammation and autoimmunity, including atherosclerosis. However, IL-6
is also produced and released under beneficial conditions, such as exercise, where IL-6 is
associated with the anti-inflammatory and metabolic effects coupled with physical
adaptation to intense training. Exercise-associated IL-6 acts on adipose tissue to
induce lipogenesis and on arteries to induce adaptative vascular remodeling. These
divergent actions could be explained by complex signaling networks. Classical IL-6
signaling involves a membrane-bound IL-6 receptor and glycoprotein 130 (gp130),
while trans-signaling relies on a soluble version of IL-6R (sIL-6R) and membranebound
gp130. Trans-signaling, but not the classical pathway, is regulated by soluble
gp130. In this review, we discuss the similarities and differences in IL-6 cytokine and
myokine signaling to explain the differential and opposite effects of this protein during
inflammation and exercise, with a special focus on the vascular system.
es_ES
Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT 1180157
1170963
FONDAP 15130011