Browsing by Author "201-0494910"
Now showing items 1-20 of 30
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(Universidad de Chile, 2008)La exposición de un órgano a situaciones de citotoxicidad moderada o transitoria le otorga protección frente a una nueva exposición citotóxica, lo que ha permitido el desarrollo del preacondicionamiento, proceso ...
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(ELSEVIER, 2006-05-01)Recently, we reported that 3,3,5-triiodothyronine (T-3) induces the expression of redox-sensitive genes as a nongenomic mechanism of T3 action. In this study, we show that T3 administration to rats (daily doses of 0. 1 ...
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(1987)The study of the influence of the age of animals (13 to 53 weeks) on total liver thiobarbituric acid reactive substances (TBAR) content showed an increase which is maximal in rats of 39 weeks of age compared to young animals ...
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(1996)Aerobic life is characterized by a steady generation of reactive oxygen species balanced by a similar rate of their consumption by antioxidants. To maintain homeostasis, there is a requirement for the continuous regeneration ...
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(Universidad de Chile, 2013)Nrf2 es un factor de transcripción que estimula la expresión de genes citoprotectores frente al estrés oxidativo (EOX). En condiciones homeostáticas Nrf2 está en el citoplasma formando un complejo con su inhibidor Keap1. ...
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(ELSEVIER, 2008-05-01)Hepatic ischemia-reperfusion (R) injury, a major clinical drawback during surgery, is abolished by L-3,3',5-triiodothyronine (T-3) administration. Considering that the triggering mechanisms are unknown, the aim of this ...
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Causal role of oxidative stress in unfolded protein response development in the hyperthyroid state (Elsevier, 2015)L-3,3',5-Triiodothyronine (T-3) induced liver oxidative stress underlies significant protein oxidation, which may trigger the unfolded protein response (UPR). Administration of daily doses of 0.1 mg T-3 for three consecutive ...
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Chemiluminescent and respiratory responses related to thyroid hormone-induced liver oxidative stress (Informa Healthcare, 1988)Chemiluminescent and respiratory responses were studied in the liver of rats treated with 0.1 mg of triiodothyronine (T)/kg for I to 7 days. Hyperthyroidism resulted in significant increments in the spontaneous chemiluminescence ...
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(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-08)Iron is an essential micronutrient promoting oxidative stress in the liver of overloaded animals and human, which may trigger the expression of redox-sensitive genes. We have tested the hypothesis that chronic iron overload ...
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(1985)Data presented here indicate that iron exposure exacerbates the changes in the glutathione status of the liver cell and the lipid peroxidative response of the tissue induced by acute ethanol intoxication. In these conditions, ...
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(1983)The administration of 125 mg of iron/kg (iron-dextran-Imferon) to fed rats was followed by an increase in the non-hem iron content in plasma and liver over a period of 22 hr, reaching a peak value after 6 hr. Plasma and ...
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(2002)Thyroid hormone-induced calorigenesis contributes to liver oxidative stress and promotes an increased respiratory burst activity in Kupffer cells, which could conceivably increase the expression of redox-sensitive genes, ...
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(1993)The effect of thyroid hormone administration on liver glutathione (GSH) content and γ-glutamyltransferase activity in the isolated perfused liver was studied for a period of 1-7 days in fed rats following a single dose of ...
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(Universidad de Chile, 1999)
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(2010)We studied the role of Kupffer cell functioning in T3 liver preconditioning against ischemia–reperfusion (IR) injury using the macrophage inactivator gadolinium chloride (GdCl3) previous to T3 treatment. Male Sprague–Dawley ...
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(Elsevier, 2011)Aims: Liver preconditioning against ischemia–reperfusion (IR) injury is a major area of experimental research, in which regulation of gene expression with cytoprotective responses due to transient oxidative stress development ...
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(2012)The liver is a major organ responsible for most functions of cellular metabolism and a mediator between dietary and endogenous sources of energy for extrahepatic tissues. In this context, adenosine-monophosphate- (AMP-) ...
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(2012)Omega-3 (n-3) long-chain polyunsaturated fatty acids (n-3 LCPUFA) are associated with several physiological functions, suggesting that their administration may prevent non transmissible chronic diseases. Therefore, we ...
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(2011)Dietary supplementation with the n-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) to rats preconditions the liver against ischemia-reperfusion (IR) injury, with reduction ...
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(2014)Sub-chronic iron (Fe) administration induces liver oxidative stress upregulating cytoprotective mechanisms that may involve redox-sensitive nuclear factor erythroid 2-related factor 2 (Nrf2). We aimed to investigate whether ...
