Now showing items 1-20 of 44

    • Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Rapoport, Stanley I. (SOCIEDAD BIOLGIA CHILE, 2006)
      Down syndrome is determined by the presence of an extra copy of autosome 21 and is expressed by multiple abnormalities, with mental retardation being the most striking feature. The condition results in altered electrical ...
    • Paris Pizarro, Irmgard; Pérez Pastene, Carolina; Cárdenas, Sergio; Iturra, Patricio; Muñoz, Patricia; Couve, Eduardo; Caviedes Fernández, Pablo; Segura Aguilar, Juan (SPRINGER, 2010-01-20)
      Abstract In previous studies, we observed that cells treated with aminochrome obtained by oxidizing dopamine with oxidizing agents dramatically changed cell morphology, thus posing the question if such morphological changes ...
    • Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Arriagada, Christian; Paris Pizarro, Irmgard; Caviedes Fernández, Pablo; Caviedes, R.; Segura Aguilar, Juan (2000)
      Angiotensin receptor II mRNA was found to be expressed in dopaminergic neuronal cell line RCSN3 of rat substantia nigra using RT-PCR reaction. Aminochrome (150 μM), a metabolite of the dopamine oxidative pathway, was found ...
    • Arriagada Abarzúa, Christian; Bustamante, Miguel; Atwater Ransom, Illani; Rojas, Eduardo; Caviedes Codelia, Raúl; Caviedes Fernández, Pablo (ELSEVIER, 2010)
      Human Down syndrome (DS) represents the most frequent cause of mental retardation associated to a genetic condition. DS also exhibits a characteristic early onset of neuropathology indistinguishable from that observed ...
    • Díaz Jara, Jorge; Woudt, Lisanne; Suazo Rojas, Lionel Andrés; Garrido Inostroza, Cristian Alejandro; Caviedes Fernández, Pablo; Cárdenas, Ana María; Bevilacqua, Jorge (2016)
      Introduction: MRI characterization of dysferlinopathy has been mostly limited to the lower limbs. We aimed to broaden the MRI description of dysferlinopathy and to correlate it with objective measures of motor dysfunction. ...
    • Bevilacqua, Jorge; Mathieu, Y.; Krahn, M.; Bartoli, M.; Castiglioni, C.; Kleinsteuber Saa, Karin; Díaz Jeraldo, Juan; Puppo, F.; Cerino, M.; Courrier, S.; Gorokhova, S.; Miranda Moreno, Natalia; Trangulao, Alejandra; González Hormazábal, Patricio; Avaria Benapres, María de los Angeles; Urtizberea, J.; Caviedes Fernández, Pablo; Jara Sosa, Lilian; Levy, N. (Pergamon-Elsevier Science, 2016)
    • Allen, David D.; Caviedes Codelia, Raúl; Cárdenas, Ana María; Shimahara, Takeshi; Segura Aguilar, Juan; Caviedes Fernández, Pablo (DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2005)
      Cell culture is highly desirable, as it provides systems for ready, direct access and evaluation of tissues. The use of tissue culture is a valuable tool to study problems of clinical relevance, especially those related ...
    • González Jamett, Arlek M.; Báez Matus, Ximena; Bui, M.; Guicheney, R.; Romero, N. B.; Caviedes Fernández, Pablo; Bitoun, M.; Bevilacqua, Jorge; Cardenas, A. (Elsevier, 2017)
    • Fernandez, G.; Bevilacqua, Jorge; Cárdenas, A.; Saez, J.; Caviedes Fernández, Pablo; Cea Pisani, Luis Andrés (Elsevier, 2017)
    • Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Baier, C. J.; Franco, D. L.; Gallegos, C.E.; Mongiat, L. A.; Dionisio, L.; Bouzat, C.; Caviedes Fernández, Pablo; Barrientos, F. J. (Elsevier, 2014)
      Chronic exposure to stress hormones has an impact on brain structures relevant to cognition. Nicotinic acetylcholine receptors (AChRs) are involved in numerous cognitive processes including learning and memory formation. ...
    • Báez Matus, Ximena; Figueroa Cares, Cindel; González Jamett, Arlek M.; Almarza Salazar, Hugo; Arriagada, Christian; Maldifassi, María Constanza; Guerra, María José; Mouly, Vincent; Bigot, Anne; Caviedes Fernández, Pablo; Cárdenas, Ana M. (MDPI, 2020)
      Dysferlin is a transmembrane C-2 domain-containing protein involved in vesicle trafficking and membrane remodeling in skeletal muscle cells. However, the mechanism by which dysferlin regulates these cellular processes ...
    • Paris Pizarro, Irmgard; Martínez Alvarado, P.; Cárdenas, S.; Pérez Pastene, C.; Graumann, Rebecca; Fuentes, P.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Segura Aguilar, Juan (AMER CHEMICAL SOC, 2005-03)
      We report a new and specific mechanism for iron-mediated neurotoxicity using RCHT cells, which were derived from rat hypothalamus. RCHT cells exhibit immunofluorescent-positive markers for dopamine beta-hydroxylase and the ...
    • González Jamett, Arlek M.; Báez Matus, Ximena; Olivares, María José; Hinostroza, Fernando; Guerra Fernández, María José; Vásquez Navarrete, Jacqueline; Bui, Mai Thao; Guicheney, Pascale; Romero, Norma; Bevilacqua, Jorge; Bitoun, Marc; Caviedes Fernández, Pablo; Cárdenas, Ana María (Nature Publishing Group, 2017)
      Dynamin-2 is a ubiquitously expressed GTP-ase that mediates membrane remodeling. Recent findings indicate that dynamin-2 also regulates actin dynamics. Mutations in dynamin-2 cause dominant centronuclear myopathy (CNM), a ...
    • González Jamett, Arlek M.; Aro Acuña, Valentina; Momboisse, Fanny; Caviedes Fernández, Pablo; Bevilacqua, Jorge; Cárdenas, Ana María (International Society for Neurochemistry, 2014)
      Dynamin-2 is a pleiotropic GTPase whose best-known function is related to membrane scission during vesicle budding from the plasma or Golgi membranes. In the nervous system, dynamin-2 participates in synaptic vesicle ...
    • Cárdenas, Ana María; González Jamett, Arlek M.; Cea Pisani, Luis Andrés; Bevilacqua, Jorge; Caviedes Fernández, Pablo (2016)
      Mutations in the dysferlin gene are linked to a group of muscular dystrophies known as dysferlinopathies. These myopathies are characterized by progressive atrophy. Studies in muscle tissue from dysferlinopathy patients ...
    • Galarce Toro, Natalia Loreto (Universidad de Chile, 2013)
      La ingeniería biomédica ha tenido un gran avance en las últimas décadas, generando biomateriales con alto potencial de uso en el área de la medicina reconstructiva, para la elaboración de prótesis o implantes que deben ser ...
    • Covarrubias Gallardo, Cristián; Arroyo Ibacache, Fabiola; Balanda Maluenda, Consuelo; Neira Jara, Miguel; Von Marttens Castro, Alfredo; Caviedes Fernández, Pablo; Rodríguez, Juan Pablo; Urra, Carla (Hindawi Publishing, 2015)
      The effect of the nanoscale structure of bioceramics on their in vitro bioactivity and capacity to osteogenically differentiate stem cell is studied. Nanoparticles of hydroxyapatite (nHA), bioactive glass (nBG), nanoporous ...
    • Beltrán Carpentier, Macarena Florencia (Universidad de Chile, 2013)
      Últimamente, ha aumentado el interés de científicos e investigadores por los materiales poliméricos con propiedades antibacterianas, es decir, polímeros a los que se les incopora un agente biocida, como el cobre, durante ...
    • Liberona Leppe, José; Caviedes Fernández, Pablo; Tascón, S.; Hidalgo Tapia, Jorge; Giglio, J. R.; Sampaio, S. V.; Caviedes, R.; Jaimovich Pérez, Enrique (Chapman Hall, 1997)
      An immortal, cloned cell Line (RCMH), obtained from human skeletal muscle was established in our laboratory and shown to express muscle specific proteins. We measured ligand binding to ion channels, ion currents using whole ...