Now showing items 1-20 of 61

    • Ponce, Iván; Aldunate, Carmen; Valenzuela, Lucía; Sepúlveda Contreras, Sofía; Garrido, Gilda; Kemmerling Weis, Ulrike; Cabrera Vallejos, Gonzalo; Galanti Garrone, Norbel (Wiley, 2017)
      FLAP endonucleases (FEN) are involved both in DNA replication and repair by processing DNA intermediaries presenting a nucleotide flap using its phosphodiesterase activity. In spite of these important functions in DNA ...
    • Åslund, Lena; Carlsson, Lars; Henriksson, Jan; Rydåker, Maria; Cecilia Toro, G.; Galanti Garrone, Norbel; Pettersson, Ulf (1994)
      A gene family encoding a set of histone H1 proteins in Trypanosoma cruzi is described. The sequence of 3 genomic and 4 cDNA clones revealed the presence of several motifs characteristic of histone H1 although heterogeneity ...
    • Liempi Manquel, Ana; Castillo Varela, Christian; Carrillo Werner, Ileana; Muñoz Clavijo, Lorena; Droguett Ossa, Daniel; Galanti Garrone, Norbel; Maya Arango, Juan; Kemmerling Weis, Ulrike (Academic Press, 2016)
      Congenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the progressive globalization of Chagas disease despite of its low transmission rate. The probability of congenital transmission depends ...
    • Paredes Esparza, Rodolfo; Jiménez Ortiz, Verónica; Cabrera Vallejos, Gonzalo; Iragüen Contreras, Daniela; Galanti Garrone, Norbel (2007)
      Echinococcus granulosus is a parasitic cestode causing hydatidosis in intermediate hosts (human and herbivorous). Most symptoms of the disease occur by the pressure exerted on viscera by cysts that are formed upon ingestion ...
    • Molina Berríos, Alfredo Enrique; Campos Estrada, Carolina; Lapier, Michel; Duaso, Juan; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel; Leiva, Mario; Ferreira, Jorge; López Muñoz, Rodrigo; Maya Arango, Juan (Elsevier, 2013)
      Objectives: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. Methods: A low (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice ...
    • Paredes, Rodolfo; Godoy, Pablo; Rodríguez, Betsabé; García, María Pía; Cabezón, Carolina; Cabrera Vallejos, Gonzalo; Jiménez, Verónica; Hellman, Ulf; Sáenz Iturriaga, Leonardo Enrique; Ferreira Vigouroux, Luis Arturo; Galanti Garrone, Norbel (WILEY-BLACKWELL PUBLISHING, 2011-01)
      Echinococcus granulosus, the agent of hydatid disease, presents an indirect life cycle, with canines (mainly dogs) as definitive hosts, and herbivores and human as intermediary ones. In intermediary hosts fertile and ...
    • Carrillo, Ileana; Castillo, Christian; Droguett, Daniel; Muñoz, Lorena; Liempi, Ana; Maya Arango, Juan; Galanti Garrone, Norbel; Kemmerling Weis, Ulrike (2016)
      Congenital Chagas’ disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi), which is able to cross the placental barrier and infect both the placenta and fetus. However, congenital transmission ...
    • Carrillo Werner, Ileana; Droguett Ossa, Daniel; Castillo Varela, Christian; Liempi Manquel, Ana; Muñoz Clavijo, Lorena; Maya Arango, Juan; Galanti Garrone, Norbel; Kemmerling Weis, Ulrike (Academic Press-Elsevier, 2016)
      Congenital Chagas disease is caused by the protozoan parasite Trypanosoma cruzi that must cross the placental barrier during transmission. The trophoblast constitutes the first tissue in contact with the maternal-blood ...
    • Teichmann, Aline; Vargas, Daiani M.; Monteiro, Karina M.; Meneghetti, Bruna V.; Dutra, Cristine S.; Paredes, Rodolfo; Galanti Garrone, Norbel; Zaha, Arnaldo; Ferreira, Henrique B. (American Chemical Society, 2015)
      The 14-3-3 protein family of eukaryotic regulators was studied in Echinococcus granulosus, the causative agent of cystic hydatid disease. These proteins mediate important cellular processes in eukaryotes and are ...
    • Kunrath Lima, Marianna; Marçal Repolês, Bruno; Alves, Ceres Luciana; Furtado, Carolina; Andrade Rajao, Matheus; Macedo, Andrea Mara; Franco, Gloria Regina; Junho Pena, Sergio Danilo; Valenzuela, Lucía; Wisnovsky, Simon; Kelley, Shana O.; Galanti Garrone, Norbel; Cabrera Vallejos, Gonzalo; Machado, Carlos Renato (Elsevier, 2017)
      Trypanosoma cruzi is a protozoan parasite and the causative agent of Chagas disease. Like most living organisms, it is susceptible to oxidative stress, and must adapt to distinct environments. Hence, DNA repair is essential ...
    • Galindo Díaz, Mario; Sabaj Diez, Valeria; Espinoza, Ingrid; Toro, Gabriela Cecilia; Búa, Jaqueline; Grenet, Jose; López Solís, Remigio; Ruiz, Andres Mariano; Galanti Garrone, Norbel (ELSEVIER SCIENCE BV, 2007-05)
      The Trypanosoma cruzi karyotype shows an extensive chromosomal size polymorphism. Absence of condensed mitotic chromosomes and chromatin fragility are characteristic features of T. cruzi which would allow DNA breaks and ...
    • Henriksson, Jan; Porcel, Betina; Rydåker, Maria; Ruiz, Andres; Sabaj, Valeria; Galanti Garrone, Norbel; Cazzulo, Juan José; Frasch, Alberto Carlos C.; Pettersson, Ulf (1995)
      The karyotypes of three cloned stocks, CL Brener (CL), CA I/72 (CA) and Sylvio X10/7 (X10), of Trypanosoma cruzi were studied by pulsed-field gel electrophoresis followed by ethidium bromide staining and hybridization with ...
    • Medina, Lisvaneth; Castillo, Christian; Liempi, Ana; Herbach, Mathias; Cabrera, Gonzalo; Valenzuela, Lucía; Galanti Garrone, Norbel; de los Angeles Curto, María; Schijman, Alejandro G.; Kemmerling Weis, Ulrike (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Congenital Chagas disease, caused by Trypanosoma cruzi (T. cruzi), has become epidemiologically relevant. The probability of congenital transmission depends on the maternal and developing fetal/newborn ...
    • Cabrera Vallejos, Gonzalo; Cabrejos, María Eugenia; Morassutti, Alessandra Loureiro; Cabezón, Carolina; Orellana, Juana; Hellman, Ulf; Zaha, Arnaldo; Galanti Garrone, Norbel (WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-08)
      Hydatidosis, caused by the larval stage of the platyhelminth parasite Echinococcus granulosus, affects human and animal health. Hydatid fertile cysts are formed in intermediate hosts (human and herbivores) producing ...
    • Rojas, M.Véronica; Galanti Garrone, Norbel (1990)
      DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5-methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence -CCGG- is not methylated. ...
    • Cabrera, G.; Barría, C.; Fernández, C. O.; Sepúlveda, S.; Valenzuela, L.; Kemmerling Weis, Ulrike; Galanti Garrone, Norbel (2011)
      Trypanosoma cruzi, a parasitic protozoan, is the etiological agent of Chagas disease, an endemic and neglected pathology in Latin America. It presents a life cycle that involves a hematophagous insect and man as well as ...
    • Galindo, Mario A.; González Burgos, María Julieta; Galanti Garrone, Norbel (Society of Biology of Chile, 2002)
      Echinococcus granulosus is a parasitic platyhelminth that is responsible for cystic hydatid disease. From the inner, germinal layer of hydatid cysts protoscoleces are generated, which are are the infective forms to the ...
    • Galindo Díaz, Mario; Schadebrodt, Gloria; Galanti Garrone, Norbel (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-08)
      Basic aspects of the generation, structure and function of Echinococcus granulosus protoscoleces are unknown. We review the work done on the structure and ultrastructure of the E. granulosus protoscolex and provide new ...
    • Jiménez, Verónica; Henríquez, Mauricio; Galanti Garrone, Norbel; Riquelme, Gloria (2011)
      Potassium channels (K+ channels) are members of one of the largest and most diverse families of membrane proteins, widely described from bacteria to humans. Their functions include voltage-membrane potential maintenance, ...
    • Santori, María I.; Laría, Sebastián; Gómez, Eliana B.; Espinosa, Ingrid; Galanti Garrone, Norbel; Téllez-Iñón, María T. (2002)
      Trypanosoma cruzi CRK3 gene encodes a Cdc2p related protein kinase (CRK). To establish if it has a role in the regulation of the parasite cell cycle we studied CRK3 expression and activity throughout three life cycle stages. ...