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Chromosomal size conservation through the cell cycle supports karyotype stability in Trypanosoma cruzi

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2007-05
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Galindo Díaz, Mario
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Chromosomal size conservation through the cell cycle supports karyotype stability in Trypanosoma cruzi
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Author
  • Galindo Díaz, Mario;
  • Sabaj Diez, Valeria;
  • Espinoza, Ingrid;
  • Toro, Gabriela Cecilia;
  • Búa, Jaqueline;
  • Grenet, Jose;
  • López Solís, Remigio;
  • Ruiz, Andres Mariano;
  • Galanti Garrone, Norbel;
Abstract
The Trypanosoma cruzi karyotype shows an extensive chromosomal size polymorphism. Absence of condensed mitotic chromosomes and chromatin fragility are characteristic features of T. cruzi which would allow DNA breaks and chromosomal rearrangements during cell proliferation. We have investigated by pulsed field gel electrophoresis (PFGE) eventual changes in chromosomal size during exponential and stationary phases of T. cruzi epimastigotes in culture, in G0 trypomastigotes and throughout the cell cycle in synchronized epimastigotes. T. cruzi molecular karyotype was stable throughout the cell cycle and during differentiation. Thus, the chromosomal size polymorphism previously reported in T. cruzi contrasts with the stability of the molecular karyotype observed here and suggests that chromosomal rearrangements leading to changes in chromosomal size are scarce events during the clonal propagation of this parasite
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Supported by a Grant from the Programa Bicentenario de Ciencia y Tecnologı´a, Proyecto Anillo ACT29, The World Bank/CONICYT, Chile.
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URI: https://repositorio.uchile.cl/handle/2250/127884
ISSN: 0014-5793
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FEBS LETTERS, v.: 581, issue: 10, p.: 2022-2026, MAY 15 2007
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