Browsing by Author "Chiong Lay, Mario"

Now showing items 21-40 of 123

    • Comparative subcellular distribution of apyrase from animal and plant sources. Characterization of microsomal ... 
      Valenzuela,; López,; Depix,; Mancilla,; Kettlun,; Catalán,; Chiong Lay, Mario; Garrido,; Traverso Cori, A. (1989)
      1. 1. Apyrase (ATP: diphosphohydrolase) has been found in the microsomal fraction of rat salivary gland, mammary gland and uterus. 2. 2. This enzyme, already described in plant tissues, is mainly present as a soluble ...
    • Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death ... 
      Aránguiz Urroz, Pablo Daniel; Soto Muñoz, Dagoberto; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Montenegro Obregón, José Joaquín; Venegas Pino, Daniel Esteban; Smolic Smolic, Christian; Ayala Jeria, Pedro Segundo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (NATURE PUBLISHING GROUP, 2009-05)
      The Angiotensin II (Ang II) type 1 (AT(1)R) and type 2 (AT(2)R) receptors are increased in the heart following myocardial infarction and dilated cardiomyopathy, yet their contribution at a cellular level to compensation ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 
      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Efecto del péptido angiotensina-(1-9) sobre la desdiferenciación de las células musculares lisas vasculares 
      Norambuena Soto, Ignacio Esteban (Universidad de Chile, 2020)
      Durante la progresión y desarrollo de las enfermedades cardiovasculares (ECV), en particular las asociadas con los vasos sanguíneos, las células de la musculatura lisa vascular (VSMC) cambian de fenotipo, pasando de uno ...
    • Efectos del carvedilol en la capacidad funcional, función ventricular izquierda, catecolaminas y estrés ... 
      Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (Sociedad Española de Cardiología, 2004)
      El carvedilol es un antagonista adrenérgico con acción antioxidante y un demostrado beneficio sobre la mortalidad en insuficiencia cardíaca (IC). El objetivo de este estudio es evaluar, en pacientes con insuficiencia ...
    • Effect of foliar nutrients, fungicides, temperature and metal ions on pectate lyase and endopolygalacturonase ... 
      Aubá, M.; Chiong Lay, Mario; Pérez Roepke, Luz María (Asociación Latinoamericana de Fitopatología, 1993)
      The properties of pectate lyase and endopolygalacturonase, produced by Alternaria alternata isolated from sooty mold infected Citrus trees were studied. These enzymes, related to plant pathogenesis, were obtained from ...
    • Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress ... 
      Castro Agüero, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2004-11)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic ... 
      Castro, Pablo; Mc-Nab, Pablo; Quintana, Juan Carlos; Bittner, Alex; Greig, Douglas; Vergara, Ismael; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Gálvez, Hernán Alejandro; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2005-10)
      Background: Our previous studies suggest that the increase in heart rate from rest to peak exercise is reduced in patients with chronic heart failure (CHF) and this is associated with increased oxidative stress, as determined ...
    • Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure 
      Castro, Pablo; Mac Nab, Paul; Quintana, Juan Pablo; Bittner, Alex; Greig, Douglas; Vergara, I.; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Olivares, Hernán Alejandro; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2005-07-15)
      Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 ...
    • Effects of Trimetazidine in Nonischemic Heart Failure: A Randomized Study 
      Winter, José Luis; Castro, Pablo F.; Quintana, Juan Carlos; Altamirano, Rodrigo; Enriquez, Andrés; Verdejo, Hugo E.; Jalil Milad, Jorge; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariángel, Víctor; Sepúlveda Morales, Luis; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (Elsevier, 2014)
      Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ...
    • Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells 
      Antileo, Elmer; Garri, Carolina; Tapia, Victoria; Muñoz, Juan Pablo; Chiong Lay, Mario; Nualart, Francisco; Lavandero González, Sergio; Díaz Fernández, Juan Cristóbal; Núñez González, Marco (American Physiological Society, 2013)
      Ferritin, a food constituent of animal and vegetal origin, is a source of dietary iron. Its hollow central cavity has the capacity to store up to 4,500 atoms of iron, so its potential as an iron donor is advantageous to ...
    • Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics 
      Bravo Sagua, Roberto; Gutiérrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodríguez, Andrea E.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Parra, Valentina; Quest, Andrew F. G.; Rothermel, Beverly A.; Lavandero González, Sergio (Elsevier, 2012)
      Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged ...
    • Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy 
      Troncoso, Rodrigo; Vicencio, José Miguel; Parra, Valentina; Nemchenko, Andriy; Kawashima, Yuki; Campo, Andrea del; Toro, Barbra; Battiprolu, Pavan K.; Aranguiz, Pablo; Chiong Lay, Mario; Yakar, Shoshana; Gillette, Thomas G.; Hill, Joseph A.; Abel, Evan Dale; LeRoith, Derek; Lavandero González, Sergio (European Society of Cardiology, 2012)
      Aims Insulin-like growth factor 1 (IGF-1) is known to exert cardioprotective actions. However, it remains unknown if autophagy, a major adaptive response to nutritional stress, contributes to IGF-1-mediated cardioprotec ...
    • Estudio de la reactividad vascular pulmonar mediada por cGMP en neonatos de oveja tratados con hemina 
      Ferrada Díaz, Javiera Constanza (Universidad de Chile, 2017)
      La regulación de la circulación pulmonar en el periodo de perinatal es fundamental en la mantención de una presión arterial media (mPAP) y una resistencia vascular disminuida. Una desregulación del tono arterial pulmonar ...
    • Estudio de las vías transduccionales que regulan la actividad metabólica de la testosterona a través de ... 
      Venegas Zúñiga, Nataly Belén (Universidad de Chile, 2016)
      El cardiomiocito, la célula contráctil del corazón, requiere el suministro continuo de energía para llevar a cabo la contracción muscular y sus diversos procesos celulares que incluyen sobrevida, crecimiento y metabolismo. ...
    • FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation 
      Vivar, Raúl; Humeres, Claudio; Muñoz, Claudia; Boza Fuentes, Pía; Bolivar, Samir; Tapia, Felipe; Lavandero González, Sergio; Chiong Lay, Mario; Díaz Araya, Guillermo (Elsevier, 2016)
      © 2015 Elsevier B.V. Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription ...
    • Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán S., Juan; Bravo Méndez, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Campo Sfeir, Andrea Estefanía del; Sanhueza Muñoz, Carlos Joaquín; Rodríguez Villarroel, Andrea Elizabeth; Vukasovic Ramírez, José Luis; Mellado, Rose Marie; Greig, Douglas; Castro, Pablo; Lavandero González, Sergio (WILEY-BLACKWELL PUBLISHING, 2009-05)
      We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. ...
    • Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán, Juan; Bravo, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Del Campo, Andrea; Sanhueza, Carlos; Rodriguez, Andrea; Vukasovic, José Luis; Mellado, Rosemarie; Greig, Douglas; Castro, Pablo F.; Lavandero González, Sergio (2009)
      We investigated the clinical response of chronic heart failure patients with β2-adrenergic receptor Gln27→Glu polymorphism treated for 6 months with carvedilol, a α/β-antagonist with antioxidant properties. The 6-min. walk ...
    • GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic ... 
      Morales, Pablo E.; Torres, Gloria; Sotomayor Torres, Cristian; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Elsevier, 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)–mitochondria ...
    • Glucagon-like peptide-1 inhibits vascular smooth muscle cell dedifferentiation through mitochondrial dynamics ... 
      Torres, Gloria; Morales, Pablo E.; García Miguel, Marina; Norambuena Soto, Ignacio; Cartes Saavedra, Benjamin; Vidal Pena, Gonzalo; Moncada Ruff, David; Sanhueza Olivares, Fernanda; San Martín, Alejandra; Chiong Lay, Mario (PERGAMON-ELSEVIER SCIENCE LTD., 2016)
      Glucagon-like peptide-1 (GLP-1) is a neuroendocrine hormone produced by gastrointestinal tract in response to food ingestion. GLP-1 plays a very important role in the glucose homeostasis by stimulating glucose-dependent ...