Browsing by Author "Maya Arango, Juan"
Now showing items 21-40 of 45
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(Bentham Science Publishers Ltd., 2008)In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of ...
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(2011)Background: Chagas disease is a health threat for many people, mostly those living in Latin America. One of the most important problems in treatment is the limitation of existing drugs. Prodigiosin, produced by Serratia ...
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(2007)Current knowledge of the biochemistry of Trypanosonta cruzi has led to the development of new drugs and the understanding of their mode of action. Some trypanocidal drugs such as nifurtimox and benznidazole act through ...
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(2011)Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side ...
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(Royal Society of Chemistry, 2019)In the search for a more effective chemotherapy for the treatment of Chagas' disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic ...
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(ELSEVIER, 2006-11)Rhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining ...
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(AMER CHEMICAL SOC, 2006-06-01)In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the ...
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(BENTHAM SCIENCE PUBL LTD., 2005-06)In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic ...
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(Elsevier, 2015)Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(eta(5)-C5H5)(PPh3)L], with HL = bioactive 5-nitrofuryl containing thiosemicarbazones were synthesized and characterized ...
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(Elsevier, 2014)Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and Africantrypanosomiasis. Despite its extensive use as antiparasitic drug, little evidence exists about the effect ofpentamidine ...
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(Elsevier, 2013)Chagas‘ disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi). During congenital transmission the parasite breaks down the placental barrier, however studies about the physiopathology of this ...
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(ELSEVIER SCIENCE INC, 2008-05)In the search for new therapeutic tools against Chagas’ disease (American Trypanosomiasis) two series of new platinum(II) complexes with bioactive 5-nitrofuryl containing thiosemicarbazones as ligands were synthesized, ...
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(Springer, 2013)In the search for new metal-based drugs against diseases produced by trypanosomatid parasites, four organoruthenium(II) compounds [Ru2(p-cymene)2(L)2] X2, where L are bioactive 5-nitrofuryl-containing thiosemicarbazones ...
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(Springer, 2013)Chronic Chagas’ disease affects 10–30 % of patients infected with Trypanosoma cruzi, and it mainly manifests as cardiomyopathy. Important pathophysiological mechanisms involved in the cardiac lesions include activation of ...
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(PLoS, 2013)Chagas’ disease, produced by Trypanosoma cruzi, affects more than 8 million people, producing approximately 10,000 deaths each year in Latin America. Migration of people from endemic regions to developed countries has ...
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(Universidad de Chile, 2022)La enfermedad de Chagas, causada por el protozoario Trypanosoma cruzi, es endémica en América Latina y está ampliamente distribuida en todo el mundo debido a la migración poblacional. Clínicamente, se caracteriza por una ...
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(2012)In Latin America, there are about 10-12 million people infected with Trypanosoma cruzi, the agent of Chagas' disease, one of the most important neglected tropical parasitism. Identification of molecular targets, specific ...
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(Universidad de Chile, 2020)La enfermedad de Chagas es una parasitosis causada por el protozoo Trypanosoma cruzi. Es endémica en Latinoamérica, pero por la migración poblacional, hay casos reportados en Europa, Japón y Australia, entre otros países. ...
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(Elsevier, 2019)Association constants and thermodynamicsparameters on inclusion of four 3-amido coumarins that present trypanocidal activity, into 6-amino-beta-cyclodextrin (1: 1 stoichimetry) were determined. In addition, pure ...
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(Elsevier, 2014)To study the electronic influence of the organometallic moieties in thiosemicarbazones, two short libraries of cyrhetrenyl thiosemicarbazone and ferrocenyl thiosemicarbazone hybrids were synthesized and tested for their ...
