Insight into the Bioreductive Mode of Action of Antitrypanosomal 5-Nitrofuryl Containing Thiosemicarbazones
MetadataShow full item record
In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated in T. cruzi by compounds´ bioreduction were analyzed. Three different patterns of ESR signals were observed for the different assayed compounds. These results were in agreement with the changes in the T. cruzi-oxygen uptake promoted by these compounds. On the other hand, free-radical scavenger properties, measured as oxygen radical absorbance capacity (ORAC), did not seem to correlate with the trypanocidal activity.
This research was partially supported by TWAS (research grant RG/CHE/LA 04-205), FONDECYT 1030949 and 1061072 grants, CONICYT AT-4040020 grant, PBCT/ CONICYT Anillo ACT 29, U. de Chile DID graduate grant PG-65. L.O. thanks RTPD and CSIC (Uruguay) for a scholarship.
Quote ItemMedicinal Chemistry, 2008, 4, 11-17