Browsing by Author "201-0500619"
Now showing items 1-20 of 38
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Tapia, Ricardo; López, Claudio; Morello Casté, Antonio; Maya Arango, Juan; Valderrama, Jaime (2005)The synthesis of a new class of angular tetracyclic quinones is described. Our strategy involves Diels-Alder reaction of pyrroloquinolinequinone 9, generated in situ from pyrroloquinoline 8, and dienes. The required ...
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Salazar, Inés; Pavani, Mario; Aranda, Waldo; Maya Arango, Juan; Morello Casté, Antonio; Ferreira, Jorge (2004)We report that oxidative phosphorylation and Ca2+ uptake processes are enhanced in liver mitochondria isolated from benzo[a]pyrene (B[a]P)-treated rats. The carcinogen did not affect either the respiratory control index ...
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Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
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Maya Arango, Juan; Orellana, Myriam; Ferreira, Jorge; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo; Morello Casté, Antonio (Society of Biology of Chile, 2010)There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma ...
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Frey, Christian; Pavani, Mario; Cordano, Gianni; Muñoz, Sergio; Rivera, Enrique; Medina, Jorge; Morello Casté, Antonio; Maya Arango, Juan; Ferrada Parker, Jorge (ELSEVIER, 2007)Alkyl esters of gallic acid inhibited the respiration rate of mouse sarcoma 786A and mouse mammary adenocarcinoma TA3 cell lines and its multiresistant variant TA3-MTX-R more effectively than gallic acid, both in the ...
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Brain Isasi, S.; Quezada Aburto, Cristián Salvador; Pessoa Mahana, Hernán; Morello Casté, Antonio; Kogan Bocian, Marcelo; Álvarez Lueje, Alejandro (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08-15)This work presents the development of analytical methodologies by UV spectrophotometry and HPLC to characterize five nitroarylbenzimidazole derivatives with activity against Trypanosoma cruzi: NB, BNB, PNB, PMNB and PCNB. ...
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Aldunate, J.; Coloma-Torres, L.; Spencer, P.; Morello Casté, Antonio; Ojeda, J. M.; Repetto Scaramelli, Yolanda (1992)Results obtained with in situ mitochondria or Trypanosoma cruzi showed that this protozoon had only two energy coupling sites, sites II and III that correspond to higher eukaryote mitochondria. Rotenone did not inhibit the ...
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Maya Arango, Juan; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Tellez Neubauer, Rowena; Rodríguez, A.; Zelada, U.; Puebla, P.; Caballero S., Esther; Medarde, M.; Núñez Vergara, Luis; Squella Serrano, Juan; Bontá, M.; Bollo Dragnic, Soledad; Feliciano M., Arturo San (PERGAMON-ELSEVIER SCIENCE, 2000-01)A series of 3-chloro-phenyl-1,4-dihydropyridine derivatives produced different degrees of inhibition of parasite growth and respiration on clone Brener, LQ and Tulahuen strains of Trypanosome cruzi epimastigotes. Respiratory ...
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Maya Arango, Juan; Rodríguez, Andrés; Pino, Laura; Pabón, Adriana; Ferreira, Jorge; Pavani, Mario; Repetto Scaramelli, Yolanda; Morello Casté, Antonio (Society of Biology of Chile, 2004)Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged ...
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Maya Arango, Juan; Repetto Scaramelli, Yolanda; Agosín, Moisés; Ojeda, José Manuel; Tellez, Rowena; Gaule, Carlos; Morello Casté, Antonio (1997)
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Rivas, Pilar; Cassels Niven, Bruce; Morello Casté, Antonio; Repetto Scaramelli, Yolanda (1999)Several β-carboline (9H-pyrido-[3,4-b]-indole) alkaloids were evaluated for in vitro trypanosomicidal activity against Trypanosoma cruzi epimastigotes belonging to two different strains (Tulahuen and LQ) showing different ...
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Ferreira, J.; Coloma, L.; Fones, E.; Letelier, M. E.; Repetto Scaramelli, Yolanda; Morello Casté, Antonio; Aldunate, J. (1988)The antioxidant food additives 2(3)-tert-butyl-4-hydroxyanisole (BHA), 2,6-di(tert-butyl)-p-cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. ...
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Morello Casté, Antonio; Letelier, María Eugenia; Aldunate, Jorge; Repetto Scaramelli, Yolanda (Universidad de Chile, 1987)
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Olea Azar, Claudio; Rigol Olsen, Carolina; Opazo, L.; Morello Casté, Antonio; Maya Arango, Juan; Repetto Scaramelli, Yolanda; Aguirre, G.; Cerecetto, Hugo; Di Maio, R.; González, M.; Porcal, Williams (SOCIEDAD CHILENA DE QUIMICA, 2003-12)The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
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Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Morello Casté, Antonio; Maya Arango, Juan; Moncada, C.; Cabrera, E.; Di Maio, R.; González, M.; Cerecetto, Hugo (TAYLOR & FRANCIS LTD, 2003-08)Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
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Repetto Scaramelli, Yolanda; Opazo, Eduardo; Maya Arango, Juan; Agosin, Moises; Morello Casté, Antonio (Elsevier Inc., 1996)Glutathione (GSH), trypanothione (T(SH)2) and glutathionyl spermidine (GSH-SP) concentrations were determined in the Tulahuen and LQ strains and the DM 28c clone of Trypanosoma cruzi. The concentrations of GSH, T(SH)2 and ...
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Gerpe, Alejandra; Aguirre, Gabriela; Boiani, Lucía; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio; Rigol Olsen, Carolina; Maya Arango, Juan; Morello Casté, Antonio; Piro, Oscar E.; Arán, Vicente J.; Azqueta, Amaia; López de Ceráin, Adela; Monge, Antonio; Rojas, María Antonieta; Yaluff, Gloria (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
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Muñoz, Orlando M.; Maya Arango, Juan; Ferreira, Jorge; Christen, Philippe; San Martín, José; López Muñoz, Rodrigo; Morello Casté, Antonio; Kemmerling Weis, Ulrike (Verlag der Zeitschrift fur Naturforschung, 2013)The extracts of several plants of Central Chile exhibited anti-Trypanosoma cruzi trypomastigotes activity. Most active extracts were those obtained from Podanthus ovatifolius, Berberis microphylla, Kageneckia oblonga, and ...
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Maya Arango, Juan; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio; Ferreira, Jorge; Faúndez, Mario; Galanti Garrone, Norbel; Ferreira Vigouroux, Luis Arturo; Morello Casté, Antonio (2007)Current knowledge of the biochemistry of Trypanosonta cruzi has led to the development of new drugs and the understanding of their mode of action. Some trypanocidal drugs such as nifurtimox and benznidazole act through ...
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Salas, Cristian O.; Faúndez, Mario; Morello Casté, Antonio; Maya Arango, Juan; Tapia, Ricardo A. (2011)Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side ...