Browsing by Author "201-0500619"
Now showing items 1-20 of 41
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(2005)The synthesis of a new class of angular tetracyclic quinones is described. Our strategy involves Diels-Alder reaction of pyrroloquinolinequinone 9, generated in situ from pyrroloquinoline 8, and dienes. The required ...
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(2004)We report that oxidative phosphorylation and Ca2+ uptake processes are enhanced in liver mitochondria isolated from benzo[a]pyrene (B[a]P)-treated rats. The carcinogen did not affect either the respiratory control index ...
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(American Chemical Society, 2014)Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
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(Universidad de ChileCyberDocs, 2010)
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(Society of Biology of Chile, 2010)There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma ...
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(ELSEVIER, 2007)Alkyl esters of gallic acid inhibited the respiration rate of mouse sarcoma 786A and mouse mammary adenocarcinoma TA3 cell lines and its multiresistant variant TA3-MTX-R more effectively than gallic acid, both in the ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2008-08-15)This work presents the development of analytical methodologies by UV spectrophotometry and HPLC to characterize five nitroarylbenzimidazole derivatives with activity against Trypanosoma cruzi: NB, BNB, PNB, PMNB and PCNB. ...
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(Universidad de Chile, 2012)La enfermedad de Chagas es causada por el protozoo flagelado Trypanosoma cruzi y afecta aproximadamente, a 8 millones de personas en América Latina. Se estima que cerca de 28 millones de personas están en riesgo de contraerla, ...
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(1992)Results obtained with in situ mitochondria or Trypanosoma cruzi showed that this protozoon had only two energy coupling sites, sites II and III that correspond to higher eukaryote mitochondria. Rotenone did not inhibit the ...
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(PERGAMON-ELSEVIER SCIENCE, 2000-01)A series of 3-chloro-phenyl-1,4-dihydropyridine derivatives produced different degrees of inhibition of parasite growth and respiration on clone Brener, LQ and Tulahuen strains of Trypanosome cruzi epimastigotes. Respiratory ...
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(Society of Biology of Chile, 2004)Proteins rich in sulfhydryl groups, such as metallothionein, are present in several strains of the parasite Trypanosoma cruzi, the etiological agent of Chagas' disease. Metallothionein-like protein concentrations ranged ...
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(1999)Several β-carboline (9H-pyrido-[3,4-b]-indole) alkaloids were evaluated for in vitro trypanosomicidal activity against Trypanosoma cruzi epimastigotes belonging to two different strains (Tulahuen and LQ) showing different ...
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(1988)The antioxidant food additives 2(3)-tert-butyl-4-hydroxyanisole (BHA), 2,6-di(tert-butyl)-p-cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. ...
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(Universidad de Chile, 1987)
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(SOCIEDAD CHILENA DE QUIMICA, 2003-12)The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
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(TAYLOR & FRANCIS LTD, 2003-08)Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
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(Elsevier Inc., 1996)Glutathione (GSH), trypanothione (T(SH)2) and glutathionyl spermidine (GSH-SP) concentrations were determined in the Tulahuen and LQ strains and the DM 28c clone of Trypanosoma cruzi. The concentrations of GSH, T(SH)2 and ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
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(Universidad de Chile, 2007)La enfermedad de Chagas constituye uno de los principales problemas en salud pública en América Latina. Las drogas disponibles en la actualidad para el tratamiento, Nifurtimox y Benznidazol no presentan una respuesta ...
