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Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes

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2000-01
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Maya Arango, Juan
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Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes
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Author
  • Maya Arango, Juan;
  • Morello Casté, Antonio;
  • Repetto Scaramelli, Yolanda;
  • Tellez Neubauer, Rowena;
  • Rodríguez, A.;
  • Zelada, U.;
  • Puebla, P.;
  • Caballero S., Esther;
  • Medarde, M.;
  • Núñez Vergara, Luis;
  • Squella Serrano, Juan;
  • Bontá, M.;
  • Bollo Dragnic, Soledad;
  • Feliciano M., Arturo San;
Abstract
A series of 3-chloro-phenyl-1,4-dihydropyridine derivatives produced different degrees of inhibition of parasite growth and respiration on clone Brener, LQ and Tulahuen strains of Trypanosome cruzi epimastigotes. Respiratory chain inhibition appears to be a posible determinant of the trypanosomicidal activity of this compounds. No difference in the action of these derivatives was found among the different parasite strains. For comparative purposes, the inhibitory effects of felodipine and nicardipine are also reported. A good correlation between toxic effects and the easiness of oxidation of the dihydripyridine ring was found. The presence of a fused ring on the dihydropyridine moiety significantly diminished the inhibitory effects.
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URI: https://repositorio.uchile.cl/handle/2250/120464
ISSN: 0742-8413
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COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY 125(1):103-109
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