Browsing by Author "201-0551676"
Now showing items 1-20 of 59
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(2005)The synthesis of a new class of angular tetracyclic quinones is described. Our strategy involves Diels-Alder reaction of pyrroloquinolinequinone 9, generated in situ from pyrroloquinoline 8, and dienes. The required ...
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(Academic Press, 2016)Congenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the progressive globalization of Chagas disease despite of its low transmission rate. The probability of congenital transmission depends ...
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(American Chemical Society, 2014)Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
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(Universidad de ChileCyberDocs, 2010)
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(2012)A series of fused tri- and tetracyclic indazoles and analogues compounds (NID) with potential antiparasitic effects were studied using voltamperometric and spectroscopic techniques. Nitroanion radicals generated by cyclic ...
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(2016)Congenital Chagas’ disease is caused by the haemophlagelated protozoan Trypanosoma cruzi (T. cruzi), which is able to cross the placental barrier and infect both the placenta and fetus. However, congenital transmission ...
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(Academic Press-Elsevier, 2016)Congenital Chagas disease is caused by the protozoan parasite Trypanosoma cruzi that must cross the placental barrier during transmission. The trophoblast constitutes the first tissue in contact with the maternal-blood ...
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(Elsevier Ltd, 2018)© 2018 Elsevier Ltd This work is related to the structural characterization of the sulfated polysaccharide from Lessonia sp and the study of its antioxidant and antiparasitic properties. Sequential extraction afforded ...
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(American Thoracic Society, 2017)
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(Elsevier, 2020)Trypanosoma cruzi, the causative agent of Chagas disease, and Toxoplasma gondii, which is responsible for Toxoplasmosis, are two parasites that cause significant protozoan zoonoses and consequently important economic losses ...
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(Elsevier, 2017)We previously demonstrated that alkyl gallates coupled to triphenylphosphine have a selective and efficient antiproliferative effect by inducing mitochondria] uncoupling in vitro due to the increased mitochondrial trans ...
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(2016)Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...
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(Universidad de Chile, 2012)La enfermedad de Chagas es causada por el protozoo flagelado Trypanosoma cruzi y afecta aproximadamente, a 8 millones de personas en América Latina. Se estima que cerca de 28 millones de personas están en riesgo de contraerla, ...
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(Universidad de Chile, 2015)La enfermedad de Chagas es causada por Trypanosoma cruzi. Este parásito desencadena una respuesta inflamatoria que tiende a controlar la infección en el hospedero. Sin embargo, la permanencia del parásito provoca la ...
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(Wiley-VCH Verlag, 2014)Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major health problem worldwide. In this work, we report the development of palladium and platinum metal complexes with 5-nitrofuryl-containing ...
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(PERGAMON-ELSEVIER SCIENCE, 2000-01)A series of 3-chloro-phenyl-1,4-dihydropyridine derivatives produced different degrees of inhibition of parasite growth and respiration on clone Brener, LQ and Tulahuen strains of Trypanosome cruzi epimastigotes. Respiratory ...
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(2012)A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
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(American Society Microbiology, 2017)
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(SOCIEDAD CHILENA DE QUIMICA, 2003-12)The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
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(TAYLOR & FRANCIS LTD, 2003-08)Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
