About
Contact
Help
Sending publications
How to publish
Advanced Search
View Item 
  •   Home
  • Facultad de Ciencias Químicas y Farmacéuticas
  • Artículos de revistas
  • View Item
  •   Home
  • Facultad de Ciencias Químicas y Farmacéuticas
  • Artículos de revistas
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse byCommunities and CollectionsDateAuthorsTitlesSubjectsThis CollectionDateAuthorsTitlesSubjects

My Account

Login to my accountRegister
Biblioteca Digital - Universidad de Chile
Revistas Chilenas
Repositorios Latinoamericanos
Tesis LatinoAmericanas
Tesis chilenas
Related linksRegistry of Open Access RepositoriesOpenDOARGoogle scholarCOREBASE
My Account
Login to my accountRegister

Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies

Artículo
Thumbnail
Open/Download
IconGerpe_Alejandra.pdf (735.9Kb)
Publication date
2006-05-15
Metadata
Show full item record
Cómo citar
Gerpe, Alejandra
Cómo citar
Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies
.
Copiar
Cerrar

Author
  • Gerpe, Alejandra;
  • Aguirre, Gabriela;
  • Boiani, Lucía;
  • Cerecetto, Hugo;
  • González, Mercedes;
  • Olea Azar, Claudio;
  • Rigol Olsen, Carolina;
  • Maya Arango, Juan;
  • Morello Casté, Antonio;
  • Piro, Oscar E.;
  • Arán, Vicente J.;
  • Azqueta, Amaia;
  • López de Ceráin, Adela;
  • Monge, Antonio;
  • Rojas, María Antonieta;
  • Yaluff, Gloria;
Abstract
A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the two parasitic strains and the two parasitic stages evaluated. Furthermore, besides its trypanocidal activity, 3-cyano-2-(4-nitrophenyl)-2H-indazole N-1-oxide showed leishmanocidal activity in the three parasitic strains evaluated. To gain insight into the mechanism of action, electrochemical behaviour, ESR experiment, inhibition of parasitic respiration and QSAR were performed.
Identifier
URI: https://repositorio.uchile.cl/handle/2250/120595
ISSN: 0968-0896
Quote Item
BIOORGANIC & MEDICINAL CHEMISTRY Volume: 14 Issue: 10 Pages: 3467-3480 Published: MAY 15 2006
Collections
  • Artículos de revistas
xmlui.footer.title
31 participating institutions
More than 73,000 publications
More than 110,000 topics
More than 75,000 authors
Published in the repository
  • How to publish
  • Definitions
  • Copyright
  • Frequent questions
Documents
  • Dating Guide
  • Thesis authorization
  • Document authorization
  • How to prepare a thesis (PDF)
Services
  • Digital library
  • Chilean academic journals portal
  • Latin American Repository Network
  • Latin American theses
  • Chilean theses
Dirección de Servicios de Información y Bibliotecas (SISIB)
Universidad de Chile

© 2020 DSpace
  • Access my account