| Author | dc.contributor.author | Gerpe, Alejandra | |
| Author | dc.contributor.author | Aguirre, Gabriela | es_CL |
| Author | dc.contributor.author | Boiani, Lucía | es_CL |
| Author | dc.contributor.author | Cerecetto, Hugo | es_CL |
| Author | dc.contributor.author | González, Mercedes | es_CL |
| Author | dc.contributor.author | Olea Azar, Claudio | es_CL |
| Author | dc.contributor.author | Rigol Olsen, Carolina | es_CL |
| Author | dc.contributor.author | Maya Arango, Juan | es_CL |
| Author | dc.contributor.author | Morello Casté, Antonio | es_CL |
| Author | dc.contributor.author | Piro, Oscar E. | es_CL |
| Author | dc.contributor.author | Arán, Vicente J. | es_CL |
| Author | dc.contributor.author | Azqueta, Amaia | es_CL |
| Author | dc.contributor.author | López de Ceráin, Adela | es_CL |
| Author | dc.contributor.author | Monge, Antonio | es_CL |
| Author | dc.contributor.author | Rojas, María Antonieta | es_CL |
| Author | dc.contributor.author | Yaluff, Gloria | es_CL |
| Admission date | dc.date.accessioned | 2009-04-07T16:10:09Z | |
| Available date | dc.date.available | 2009-04-07T16:10:09Z | |
| Publication date | dc.date.issued | 2006-05-15 | |
| Cita de ítem | dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY Volume: 14 Issue: 10 Pages: 3467-3480 Published: MAY 15 2006 | en |
| Identifier | dc.identifier.issn | 0968-0896 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/120595 | |
| Abstract | dc.description.abstract | A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the two parasitic strains and the two parasitic stages evaluated. Furthermore, besides its trypanocidal activity, 3-cyano-2-(4-nitrophenyl)-2H-indazole N-1-oxide showed leishmanocidal activity in the three parasitic strains evaluated. To gain insight into the mechanism of action, electrochemical behaviour, ESR experiment, inhibition of parasitic respiration and QSAR were performed. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en |
| Keywords | dc.subject | POTENTIAL ANTITRYPANOSOMAL DRUGS | en |
| Título | dc.title | Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies | en |
| Document type | dc.type | Artículo de revista | |
