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Authordc.contributor.authorOtero, Lucía 
Authordc.contributor.authorMaya Arango, Juan es_CL
Authordc.contributor.authorMorello Casté, Antonio es_CL
Authordc.contributor.authorRigol, C. es_CL
Authordc.contributor.authorBarriga, Germán es_CL
Authordc.contributor.authorRodríguez, J. es_CL
Authordc.contributor.authorFolch, C. es_CL
Authordc.contributor.authorNorambuena, Ester es_CL
Authordc.contributor.authorGonzález, M. es_CL
Authordc.contributor.authorOlea Azar, Claudio es_CL
Authordc.contributor.authorCerecetto, Hugo es_CL
Authordc.contributor.authorGambino, Dinorah es_CL
Admission datedc.date.accessioned2010-03-30T14:40:58Z
Available datedc.date.available2010-03-30T14:40:58Z
Publication datedc.date.issued2008
Cita de ítemdc.identifier.citationMedicinal Chemistry, 2008, 4, 11-17en_US
Identifierdc.identifier.issn1573-4064
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/128420
Abstractdc.description.abstractIn order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated in T. cruzi by compounds´ bioreduction were analyzed. Three different patterns of ESR signals were observed for the different assayed compounds. These results were in agreement with the changes in the T. cruzi-oxygen uptake promoted by these compounds. On the other hand, free-radical scavenger properties, measured as oxygen radical absorbance capacity (ORAC), did not seem to correlate with the trypanocidal activity.en_US
Patrocinadordc.description.sponsorshipThis research was partially supported by TWAS (research grant RG/CHE/LA 04-205), FONDECYT 1030949 and 1061072 grants, CONICYT AT-4040020 grant, PBCT/ CONICYT Anillo ACT 29, U. de Chile DID graduate grant PG-65. L.O. thanks RTPD and CSIC (Uruguay) for a scholarship.en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherBentham Science Publishers Ltd.en_US
Keywordsdc.subjectChagas diseaseen_US
Títulodc.titleInsight into the Bioreductive Mode of Action of Antitrypanosomal 5-Nitrofuryl Containing Thiosemicarbazonesen_US
Document typedc.typeArtículo de revistaen_US


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