| Author | dc.contributor.author | Otero, Lucía | |
| Author | dc.contributor.author | Maya Arango, Juan | es_CL |
| Author | dc.contributor.author | Morello Casté, Antonio | es_CL |
| Author | dc.contributor.author | Rigol, C. | es_CL |
| Author | dc.contributor.author | Barriga, Germán | es_CL |
| Author | dc.contributor.author | Rodríguez, J. | es_CL |
| Author | dc.contributor.author | Folch, C. | es_CL |
| Author | dc.contributor.author | Norambuena, Ester | es_CL |
| Author | dc.contributor.author | González, M. | es_CL |
| Author | dc.contributor.author | Olea Azar, Claudio | es_CL |
| Author | dc.contributor.author | Cerecetto, Hugo | es_CL |
| Author | dc.contributor.author | Gambino, Dinorah | es_CL |
| Admission date | dc.date.accessioned | 2010-03-30T14:40:58Z | |
| Available date | dc.date.available | 2010-03-30T14:40:58Z | |
| Publication date | dc.date.issued | 2008 | |
| Cita de ítem | dc.identifier.citation | Medicinal Chemistry, 2008, 4, 11-17 | en_US |
| Identifier | dc.identifier.issn | 1573-4064 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128420 | |
| Abstract | dc.description.abstract | In order to get insight into the trypanocidal mechanism of action of a series of 5-nitrofuryl containing thiosemicarbazones
some studies related to their bioreduction were performed. Electron spin resonance spectra of radicals generated
in T. cruzi by compounds´ bioreduction were analyzed. Three different patterns of ESR signals were observed for the
different assayed compounds. These results were in agreement with the changes in the T. cruzi-oxygen uptake promoted
by these compounds. On the other hand, free-radical scavenger properties, measured as oxygen radical absorbance capacity
(ORAC), did not seem to correlate with the trypanocidal activity. | en_US |
| Patrocinador | dc.description.sponsorship | This research was partially supported by TWAS (research
grant RG/CHE/LA 04-205), FONDECYT 1030949
and 1061072 grants, CONICYT AT-4040020 grant, PBCT/
CONICYT Anillo ACT 29, U. de Chile DID graduate grant
PG-65. L.O. thanks RTPD and CSIC (Uruguay) for a scholarship. | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | Bentham Science Publishers Ltd. | en_US |
| Keywords | dc.subject | Chagas disease | en_US |
| Título | dc.title | Insight into the Bioreductive Mode of Action of Antitrypanosomal 5-Nitrofuryl Containing Thiosemicarbazones | en_US |
| Document type | dc.type | Artículo de revista | |
