Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies
In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic voltammetry and electron spin resonance spectroscopy were used to predict the bio-reduction processes. Effects on the parasitic respiration were studied.
This research was supported by FONDECYT 1000834, 7040037, 1020095, CSIC (UdelaR), CLEMENTE ESTABLE and TWAS grants. We thank a scholarship for C. Rigol from RELACQ.
Quote ItemLETTERS IN DRUG DESIGN & DISCOVERY V.: 2, issue: 4, p.: 294-301: JUN 2005