Browsing by Author "Díaz Araya, Guillermo"

Now showing items 41-60 of 118

    • EPAC expression and function in cardiac fibroblasts and myofibroblasts 
      Olmedo, Ivonne; Muñoz, Claudia; Guzmán, Nancy; Catalán, Mabel; Vivar, Raúl; Ayala, Pedro; Humeres Martínez, Claudio; Aránguiz, Pablo; García Nannig, Lorena; Velarde, Victoria; Díaz Araya, Guillermo (Elsevier, 2013)
      In the heart, cardiac fibroblasts (CF) and cardiac myofibroblasts (CMF) are the main cells responsible for wound healing after cardiac insult. Exchange protein activated by cAMP (EPAC) is a downstream effector of cAMP, ...
    • Estrés crónico intermitente aplicado en ratas durante el período de gestación induce "programming" sobre ... 
      Bahamondes Vidal, Gabriela Catalina (Universidad de Chile, 2011)
      La exposición al frío, activa los nervios simpáticos periféricos y aumenta la tasa de recambio de noradrenalina en órganos con inervación simpática. Este aumento de las concentraciones de noradrenalina en una madre gestante ...
    • Estudio de un antioxidante de origen natural en la prevención de efectos dañinos de los oligómeros del ... 
      Lobos Zambrano, Pedro Elizardo (Universidad de Chile, 2016)
      "La Astaxantina protege a las neuronas de cultivo primario de hipocampo de los efectos dañinos de los oligómeros del peptido β-amiloide " Introducción: El incremento en la producción de especies reactivas de oxígeno y la ...
    • Evaluación de las técnicas de diferencial semántico y encuesta de actitud, para medir imagen de los ... 
      Parra Varas, José Julián (Universidad de ChilePrograma Cybertesis, 2006)
      En el siguiente trabajo de investigación se mide la imagen de marca de dos laboratorios farmacéuticos nacionales (Laboratorio L1 y Laboratorio L2) y además se determinan las actitudes de médicos especialistas en las áreas ...
    • Expresión y función de EPAC-1 en fibroblastos y miofibroblastos cardiacos 
      Olmedo Alegría, Ivonne Odette (Universidad de Chile, 2012)
      Las enfermedades cardiovasculares son, hoy en día, una de las principales causas de muerte. Estas enfermedades generan comúnmente cambios en la estructura del corazón que conlleva a un remodelamiento del tejido generando ...
    • Expresión y función de los receptores de cininas en fibroblastos y miofibroblastos cardíacos 
      Boza Fuentes, Pía (Universidad de Chile, 2012)
      Los fibroblastos son las principales células impulsoras del proceso fibrótico en el corazón. Estas células son activadas tanto por estrés mecánico, como también por citoquinas, entre ellas TGF-β1, que actúa promoviendo ...
    • Expression and function of TLR4-induced B1R bradykinin receptor on cardiac fibroblasts 
      Muñoz Rodríguez, Claudia Muriel; Fernández, Samuel; Osorio, Jose Miguel; Olivares, Francisco; Anfossi, Renatto; Bolivar, Samir; Humeres, Claudio; Boza Fuentes, Pía; Vivar, Raúl; Pardo Jiménez, Viviana Gladys; Hemmings, Karen E.; Turner, Neil A.; Díaz Araya, Guillermo (Elsevier, 2018)
      Cardiac fibroblasts (CF) are key cells for maintaining extracellular matrix (ECM) protein homeostasis in the heart, and for cardiac repair through CF-to-cardiac myofibroblast (CMF) differentiation. Additionally, CF play ...
    • Extracellular regulated kinase, but not protein kinase C, is an antiapoptotic signal of insulin-like growth ... 
      Foncea Avila, Rocío; Gálvez, Anita; Pérez Montes, Viviana; Morales, María Paz; Calixto, Andrea; Meléndez Vergara, Jaime; González Jara, Fabián Rodrigo; Díaz Araya, Guillermo; Sapag Hagar, Mario; Sugden, Peter H.; LeRoith, Derek; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-07-05)
      This study aims to elucidate the signaling pathway for insulin-like growth factor-1 (IGF-1) in cultured neonatal rat cardiomyocytes and particularly the role of IGF-1 in cardiac apoptosis, IGF-1 stimulated polyphosphoinositide ...
    • Fibroblast Primary Cilia Are Required for Cardiac Fibrosis 
      Villalobos, Elisa; Criollo Céspedes, Alfredo; Schiattarella, Gabriele G.; Altamirano, Francisco; French, Kristin M.; May, Herman I.; Jiang, Nan; Nguyen, Ngoc Uyen Nhi; Romero, Diego; Roa, Juan Carlos; García Nannig, Lorena; Díaz Araya, Guillermo; Morselli, Eugenia; Ferdous, Anwarul (NLM (Medline), 2019)
      BACKGROUND: The primary cilium is a singular cellular structure that extends from the surface of many cell types and plays crucial roles in vertebrate development, including that of the heart. Whereas ciliated cells have ...
    • FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation 
      Vivar, Raúl; Humeres, Claudio; Muñoz, Claudia; Boza Fuentes, Pía; Bolivar, Samir; Tapia, Felipe; Lavandero González, Sergio; Chiong Lay, Mario; Díaz Araya, Guillermo (Elsevier, 2016)
      © 2015 Elsevier B.V. Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription ...
    • Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán S., Juan; Bravo Méndez, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Campo Sfeir, Andrea Estefanía del; Sanhueza Muñoz, Carlos Joaquín; Rodríguez Villarroel, Andrea Elizabeth; Vukasovic Ramírez, José Luis; Mellado, Rose Marie; Greig, Douglas; Castro, Pablo; Lavandero González, Sergio (WILEY-BLACKWELL PUBLISHING, 2009-05)
      We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. ...
    • Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán, Juan; Bravo, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Del Campo, Andrea; Sanhueza, Carlos; Rodriguez, Andrea; Vukasovic, José Luis; Mellado, Rosemarie; Greig, Douglas; Castro, Pablo F.; Lavandero González, Sergio (2009)
      We investigated the clinical response of chronic heart failure patients with β2-adrenergic receptor Gln27→Glu polymorphism treated for 6 months with carvedilol, a α/β-antagonist with antioxidant properties. The 6-min. walk ...
    • Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured ... 
      Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • H2O2 activates matrix metalloproteinases through the nuclear factor kappa B pathway and Ca2+ signals in ... 
      Osorio, C.; Cavalla, F.; Paula Lima, Andrea; Díaz Araya, Guillermo; Vernal Astudillo, Rolando; Ahumada, P.; Gamonal Aravena, Jorge Antonio; Hernández, M. (Wiley & Sons, 2015)
      BackgroundThe mechanisms involved in reactive oxygen species and matrix metalloproteinase (MMP)-mediated periodontal tissue breakdown are unknown. ObjectiveTo determine the effect of H2O2 in MMP-2 and MMP-9 activity, ...
    • Heparán sulfato vía TLR4 induce la expresión de ICAM-1 y VCAM-1 y aumenta la adhesión de leucocitos a ... 
      Olivares Silva, Francisco Javier (Universidad de Chile, 2016)
      Los fibroblastos cardíacos (FC) son considerados células centinelas del tejido cardíaco, por su compleja y variada respuesta en la mantención de la homeostasis o frente a un evento de injuria cardíaca, como infarto al ...
    • Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2006-06-12)
      NF kappa B is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NF kappa B pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase ...
    • Hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (2006)
      NFκB is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NFκB pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase and cell ...
    • Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in ... 
      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibáñez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (ELSEVIER, 2006-08-07)
      We have recently shown that hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFKB is regulated in cultured ...
    • Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured ... 
      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibañez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (2006)
      We have recently shown that hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFκB is regulated in cultured rat ...
    • IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent 
      Díaz Araya, Guillermo; Borg, T. K.; Lavandero González, Sergio; Loftis, M. J.; Carver, W. (TAYLOR & FRANCIS LTD, 2003-05)
      The collagenous extracellular matrix (ECM) forms a stress-tolerant network that is essential for proper function of the vertebrate heart. Profound changes have been detected in the interstitial ECM concurrent with developmental ...