Browsing by Title
Now showing items 6816-6835 of 92398
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(1996)Antimitochondrial antibodies (AMA) are characteristically present in the serum of patients with primary biliary cirrhosis (PBC). AMA detection constitutes an important step for the clinical diagnosis of PBC, the indirect ...
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(Universidad de Chile, 2007)El presente trabajo mostró la actividad antinociceptiva de 2 tipos de AINEs, dexibuprofeno y dexketoprofeno, siendo el dexibuprofeno de mayor efectividad que el dexketoprofeno. Estos resultados se explican por la ...
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(2011)Statins, belonging to a well-known drug class used for lowering cholesterol through competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, also have other pleiotropic properties, such as ...
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(2011)Atorvastatin is a statin that inhibits the 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. Several landmark clinical trials have demonstrated the beneficial effects of statin therapy for primary and secondary ...
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(Quintessence Publishing Co. Inc., 2018)© Quintessenz. Aims: To evaluate in mice the antinociceptive effect of copper in spinal and trigeminal nociceptive pathways by using the intraplantar and orofacial formalin tests, respectively, and to examine whether this ...
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(Elsevier, 2018-06)Background: Neuropathic pain, and subsequent hypernociception, can be induced in mice by paclitaxel (PTX) administration and partial sciatic nerve ligation (PSNL). Its pharmacotherapy has been a clinical challenge, due to ...
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(Elsevier Inc., 1998)The mechanism of action of tramadol includes the activation of opioid receptors, and the potential ability of the drug to induce tolerance and physical dependence has been evaluated in different animal species and humans. ...
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(2008-09-02)Ethnopharmacological relevance: Leaf extracts of Buddleja globosa (Buddlejaceae) are used in Chilean folk medicine for wound healing. The anti-inflammatory (topic and per as), analgesic (per os) effects and the antioxidant ...
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(Elsevier, 2011-01-07)Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The ...
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(2012)Preclinical studies have demonstrated antinociceptive synergism between dexketoprofen (DEX) and tramadol (TRM) in acute animal models of nociception. The aim of the present study was to investigate the type of interaction ...
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(2008)We assessed whether intrathecal administration of the uncompetitive and competitive NMDA receptor antagonists ketamine and (±)CPP, respectively, could produce differential modulation on chemical and mechanical nociception ...
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(2001)The antinociceptive effect of clomipramine was studied in monoarthritic rats by using the paw pressure test and the C-fiber-evoked reflex. Monoarthritis was produced by intra-articular injection of complete Freund's adjuvant ...
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(The Scientific World Journal, 2012)N-methyl-D-aspartic acid receptor (NMDAr) activation requires the presence ofD-serine, synthesized from L-serine by a pyridoxal 5 -phosphate-dependent serine racemase (SR). D-serine levels can be lowered by inhibiting the ...
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(1992)The antinociceptive action of four Ca2+ channel blockers, nifedipine, nimodipine, verapamil and diltiazem, was evaluated and compared to that of morphine using three algesiometric tests in mice and rats, namely, formalin, ...
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(Elsevier Inc., 2010)The development of morphine-tolerance after chronic administration, reduces analgesic efficacy and is a significant clinical problem in some patients; may be managed clinically by increasing the doses of morphine and/or ...
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(2012)Introduction: Multiple studies have shown that glial cells of the spinal cord, such as astrocytes and microglia, have close contact with neurons, suggesting the term tripartite synapse. In these synapses, astrocytes ...
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(Birkhauser Verlag AG, 2017)© 2017, Springer International Publishing. Objective: Diabetic neuropathy (DN) is the most common complication of diabetes and pain is one of the main symptoms of diabetic neuropathy, however, currently available drugs are ...
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(Nordic Association for the Publication of BCPT, 2016)Neuropathic pain is the result of injury to the nervous system, and different animal models have been established to meet the manifestations of neuropathy. The pharmacotherapy for neuropathic pain includes gabapentin and ...
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(Karger, 2015)Background and Methods: Neuropathic pain results from nerve injury, and gabapentin, an antiepileptic drug, has been approved for the treatment of several types of neuropathic pain. On the other hand, nortriptyline, an ...
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(Universidad de Chile, 2019)El abuso sexual infantil es un delito de gran connotación social en virtud de la desprotección de la víctima al aprovecharse de ingenuidad y dependencia. Para la protección de las víctimas menores de edad en los delitos ...