Now showing items 81-100 of 312

    • Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Copaja Soto, Miguel; Valenzuela, Rodrigo; Saldaña, Adiela; Ocaranza, María Paz; Jalil Milad, Jorge; Vio, Carlos; Lijnen, Paul; Ordenes, Gamaliel; Vivar Sánchez, Raúl; Lavandero González, Sergio; Díaz Araya, Guillermo (SAGE PUBLICATIONS LTD, 2008-09)
      Introduction. Isoproterenol treatment of Brown Norway Lewis rats (high and low plasma angiotersin-I-converting enzyme activity., respectively) results in similar cardiac hypertrophy but higher cardiac fibrosis in Brown ...
    • Gálvez, Anita; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (EDICIONES DOYMA S/L, 2001-11)
      Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ...
    • Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (Sociedad Española de Cardiología, 2004)
      El carvedilol es un antagonista adrenérgico con acción antioxidante y un demostrado beneficio sobre la mortalidad en insuficiencia cardíaca (IC). El objetivo de este estudio es evaluar, en pacientes con insuficiencia ...
    • Ocaranza, María Paz; Palomera, Cristián; Román, Maritza; Bargetto, Jorge; Lavandero González, Sergio; Jalil Milad, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)
      To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ...
    • Lavandero González, Sergio; Foncea Avila, Rocío; Pérez, V.; Sapag Hagar, Mario (ELSEVIER SCIENCE BV, 1998-01-30)
      IGF-1 increased 2-fold protein synthesis in cardiac myocytes. Genistein, whether added during preincubation or with IGF-I at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, ...
    • Jalil Milad, Jorge; Ebensperger González, Roberto; Meléndez Vergara, Jaime; Acevedo, E.; Sapag Hagar, Mario; González Jara, Fabián Rodrigo; Gálvez, Anita; Pérez Montes, Viviana; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 1999-03-26)
      There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the ...
    • Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Greig, Douglas; Alcaíno Olivares, Hernán Alejandro; Bustos Contreras, Carlos Andrés; Vukasovic Ramírez, José Luis; Godoy, Iván; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2007-03-06)
      Meeting Abstract
    • Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso, Rodrigo; Padilla, Ivonne; Vukasovic, Jose L.; Corbalán, Ramón; Lavandero González, Sergio (Ediciones Doyma, S.L., 2004)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Castro Agüero, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2004-11)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Castro, Pablo; Mc-Nab, Pablo; Quintana, Juan Carlos; Bittner, Alex; Greig, Douglas; Vergara, Ismael; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Gálvez, Hernán Alejandro; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2005-10)
      Background: Our previous studies suggest that the increase in heart rate from rest to peak exercise is reduced in patients with chronic heart failure (CHF) and this is associated with increased oxidative stress, as determined ...
    • Castro, Pablo; Mac Nab, Paul; Quintana, Juan Pablo; Bittner, Alex; Greig, Douglas; Vergara, I.; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Olivares, Hernán Alejandro; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2005-07-15)
      Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 ...
    • Castro, Pablo; Díaz Araya, Guillermo; Nettle Danniels, Maurice; Corbalán, Ramón; Pérez, Osvaldo; Nazzal Nazal, Carolina; Larrain, Germán; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2002-01-15)
      It has been reported that patients with congestive heart failure (CHF) have increased breath pentane content, conjugated diene levels, and plasma malondialdehyde (MDA) levels, an indirect marker of lipid peroxidation.(1-3) ...
    • Winter, José Luis; Castro, Pablo F.; Quintana, Juan Carlos; Altamirano, Rodrigo; Enriquez, Andrés; Verdejo, Hugo E.; Jalil Milad, Jorge; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda, Pablo; Rossel Mariángel, Víctor; Sepúlveda Morales, Luis; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (Elsevier, 2014)
      Objectives: Heart failure (HF) is associated with changes in myocardial metabolism that lead to impairment of contractile function. Trimetazidine (TMZ) modulates cardiac energetic efficiency and improves outcomes in ...
    • Osorio Fuentealba, César; Contreras Ferrat, Ariel Eduardo; Altamirano, Francisco; Espinosa Escalona, Berta; Li, Qing; Niu, Wenyan; Lavandero González, Sergio; Klip, Amira; Jaimovich Pérez, Enrique (American Diabetes Association, 2013)
      Skeletal muscle glucose uptake in response to exercise is preserved in insulin-resistant conditions, but the signals involved are debated. ATP is released from skeletal muscle by contractile activity and can autocrinely ...
    • Osorio Fuentealba, César; Contreras Ferrat, Ariel Eduardo; Altamirano, Francisco; Espinosa, Alejandra; Li, Qing; Niu, Wenyan; Lavandero González, Sergio; Klip, Amira; Jaimovich Pérez, Enrique (2013)
      Skeletal muscle glucose uptake in response to exercise is preserved in insulin-resistant conditions, but the signals involved are debated. ATP is released from skeletal muscle by contractile activity and can autocrinely ...
    • Morales, Pablo E.; Arias Durán, Carla; Ávalos Guajardo, Yáreni; Aedo, Geraldine; Verdejo, Hugo E.; Parra Ortiz, Valentina; Lavandero González, Sergio (Elsevier, 2020)
      Healthy mitochondrial function is imperative for most tissues, but especially those with a high energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular disease has demonstrated that mitochondrial ...
    • Ocaranza, María Paz; Godoy, Iván; Jalil Milad, Jorge; Varas, Manuel; Collantes, Patricia; Pinto, Melissa; Román, Maritza; Ramírez, Cristián; Copaja, Miguel; Díaz Araya, Guillermo; Castro, Pablo; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2006-10)
      The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels, circulating angiotensin (Ang) levels [Ang ...
    • Antileo, Elmer; Garri, Carolina; Tapia, Victoria; Muñoz, Juan Pablo; Chiong Lay, Mario; Nualart, Francisco; Lavandero González, Sergio; Díaz Fernández, Juan Cristóbal; Núñez González, Marco (American Physiological Society, 2013)
      Ferritin, a food constituent of animal and vegetal origin, is a source of dietary iron. Its hollow central cavity has the capacity to store up to 4,500 atoms of iron, so its potential as an iron donor is advantageous to ...
    • Bravo Sagua, Roberto; Gutiérrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodríguez, Andrea E.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Parra, Valentina; Quest, Andrew F. G.; Rothermel, Beverly A.; Lavandero González, Sergio (Elsevier, 2012)
      Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged ...