Browsing by Title

Now showing items 9162-9181 of 91734

    • Autophagy and its impact on neurodegenerative diseases: new roles for TDP-43 and C9orf72 
      Budini, Mauricio; Buratti, Emanuele; Morselli, Eugenia; Criollo Céspedes, Alfredo (Frontiers, 2017-05-30)
      Autophagy is a catabolic mechanism where intracellular material is degraded by vesicular structures called autophagolysosomes. Autophagy is necessary to maintain the normal function of the central nervous system (CNS), ...
    • Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? 
      Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; García Nannig, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • Autophagy as a therapeutic target in cardiovascular disease 
      Nemchenko, Andriy; Chiong Lay, Mario; Turer, Aslan; Lavandero González, Sergio; Hill, Joseph A. (2011)
      The epidemic of heart failure continues apace, and development of novel therapies with clinical efficacy has lagged. Now, important insights into the molecular circuitry of cardiovascular autophagy have raised the prospect ...
    • Autophagy impairment: A crossroad between neurodegeneration and tauopathies 
      Nassif, Melissa; Hetz Flores, Claudio (2012)
      Most neurodegenerative diseases involve the accumulation of misfolded proteins in the nervous system. Impairment of protein degradation pathways such as autophagy is emerging as a consistent and transversal pathological ...
    • Autophagy in aging-related oral diseases 
      Peña Oyarzún, Daniel; San Martin, Carla; Hernández Cáceres, María Paz; Lavandero González, Sergio Alejandro; Morselli, Eugenia; Budini Budini, Mauricio Fernando; Burgos, Patricia V.; Criollo Céspedes, Alfredo Guillermo (Frontiers Media, 2022)
      Autophagy is an intracellular degradation mechanism that allows recycling of organelles and macromolecules. Autophagic function increases metabolite availability modulating metabolic pathways, differentiation and cell ...
    • Autophagy in Cardiac Physiology and Disease 
      Hill, Joseph A.; Rothermel, Beverly A.; Lavandero González, Sergio (Elsevier, 2012)
    • Autophagy in cardiovascular biology 
      Lavandero González, Sergio; Chiong Lay, Mario; Rothermel, Beverly A.; Hill, Joseph A. (American Society for Clinical Investigation, 2015)
      Cardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing ...
    • Autophagy in hepatic adaptation to stress 
      Hazari, Younis M.; Bravo San Pedro, José Manuel; Hetz Flores, Claudio; Galluzzi, Lorenzo; Kroemer, Guido (Elsevier, 2020)
      Autophagy is an evolutionarily ancient process whereby eukaryotic cells eliminate disposable or potentially dangerous cytoplasmic material, to support bioenergetic metabolism and adapt to stress. Accumulating evidence ...
    • Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes 
      Mattar, Pamela; Bravo Sagua, Roberto; Tobar, Nicolás; Fuentes, Cecilia; Troncoso, Rodrigo; Breitwieser, Gerda; Lavandero González, Sergio; Cifuentes, Mariana (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. Obesity is a major current public health problem worldwide due to the severe co-morbid conditions that this disease entails. The development of obesity-related cardiometabolic disorders is in direct ...
    • Autophagy mediates tumor necrosis factor-alpha-induced phenotype switching in vascular smooth muscle A7r5 cell line 
      García Miguel, Marina; Riquelme, Jaime A.; Norambuena Soto, Ignacio; Morales, Pablo E.; Sanhueza Olivares, Fernanda; Núñez Soto, Constanza Belén; Mondaca Ruff, David; Cancino Arenas, Nicole; San Martín, Alejandra; Chiong Lay, Mario (Public library science, 2018)
      Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis ...
    • Autophagy meets fused in sarcoma-positive stress granules 
      Matus, Soledad; Bosco, Daryl A.; Hetz Flores, Claudio (Elsevier, 2014)
      Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures ...
    • Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line 
      Paris Pizarro, Irmgard; Muñoz, Patricia; Huenchuguala, Sandro; Couve, Eduardo; Sanders, Laurie H.; Greenamyre, John Timothy; Caviedes, Pablo; Segura Aguilar, Juan (2011)
      Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
    • Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora ... 
      Silva, Victor D.A.; Urriola Cuevas, Carlos; Muñoz, Patricia; Villa, Monica; Ahumada-Castro, Ulises; Huenchuguala, Sandro; Dos Santos, Cleonice C.; De Araujo, Fillipe M.; Ferreira, Rafael; Da Silva, Vanessa B.; Silva, Juliana H.C.; Soares, Érica N.; Velozo, Eudes S.; Segura Aguilar, Juan (Academia Brasileira de Ciencias, 2017)
      © 2017, Academia Brasileira de Ciencias. All rights reserved. Prosopis juliflora is a shrub that has been used to feed animals and humans. However, a synergistic action of piperidine alkaloids has been suggested to be ...
    • Autophosphorylation of carboxy-terminal residues inhibits the activity of protein kinase CK1α 
      Budini, Mauricio; Jacob, Germaine; Jedlicki, Ana; Pérez, Carolina; Allende, Catherine C.; Allende, Jorge E. (2009)
      CK1 constitutes a protein kinase subfamily that is involved in many important physiological processes. However, there is limited knowledge about mechanisms that regulate their activity. Isoforms CK1δ and CKlε were previously ...
    • Autopistas y urbanización en la comuna de Quilicura, 1970-2005 
      López Azócar, Víctor Antonio (Universidad de Chile, 2023)
    • Autopoiesis: The organization of living systems, its characterization and a model 
      Varela,; Maturana, Daniel; Uribe, (1974)
      We formulate the organization of living organisms through the characterization of the class of autopoietic systems to which living things belong. This general characterization is seen at work in a computer simulated model ...
    • Autoproducción de la amenaza ambiental en la sociedad contemporánea 
      Arnold Cathalifaud, Marcelo (Universidad de Chile. Departamento de Antropología, 2003-09)
      En este artículo se plantea la tesis que los procesos de diferenciación funcional, aunque refuerzan estructuralmente la viabilidad del sistema societal global y sus parcialidades, dejan espacios rezagados y de alta fragilidad ...
    • Autoproducción de subjetividades fronterizas en la poesía actual de mujeres mapuche 
      Moraga, Fernanda (Universidad de Chile, 2012)
    • La Autoproducción del Conflicto Mapuche en las Semánticas del Estado de Chile y la Coordinadora Arauco-Malleco. ... 
      Silva Rivas, Fernando Wladimir (Universidad de Chile, 2012)
      A pesar del carácter histórico del conflicto entre el Estado de Chile y el Pueblo Mapuche, los cambios en la estructura de la sociedad, como la diferenciación funcional y la consolidación de una sociedad mundial, afectaron ...
    • Autopsia AXD-66 
      Orellana Fernández, Rocío (Universidad de Chile, 2005)
      Abarcando todos los criterios, ciencias y creencias, el “azar” ha estado en algún momento presente. Desde tiempos inmemoriables, el hombre ha experimentado, creyendo en sí mismo y creando cosas que aparecen sin ser pensadas ...