Browsing by Author "Carrasco Pozo, Catalina"
Now showing items 1-20 of 28
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Carrasco Pozo, Catalina; Gotteland, Martín; Castillo, Rodrigo; Chen, Chen (Elsevier, 2015)Cholesterol plays an important role in inducing pancreatic beta-cell dysfunction, characterized by an impaired insulin secretory response to glucose, representing a hallmark of the transition from pre-diabetes to diabetes. ...
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Carrasco Pozo, Catalina; Gotteland, Martin; Castillo, Rodrigo L.; Chen, Chen (Academic Press Inc., 2015)© 2015 Elsevier Inc. Cholesterol plays an important role in inducing pancreatic β-cell dysfunction, characterized by an impaired insulin secretory response to glucose, representing a hallmark of the transition from ...
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Carrasco Pozo, Catalina; Gotteland, Martin; Speisky Cosoy, Hernán (2011)The aim of this work was to investigate the role of mitochondrial dysfunction in the development of oxidative stress and cytotoxicity induced by indomethacin and to evaluate the potential of an apple peel polyphenol extract ...
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Carrasco Pozo, Catalina; Speisky Cosoy, Hernán; Brunser, Oscar; Pastene, Edgar; Gotteland, Martin (2011)The stability of an apple peel polyphenol extract (APPE) with powerful antioxidant activity was evaluated under acidic conditions in vitro, and its protective effect against gastrointestinal damage was investigated in rats ...
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O'Brien, Peter; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (ELSEVIER, 2006-01-05)The increasing recognition of the participation of free radical-mediated oxidative events in the initiation and/or progression of cardiovascular, tumoural, inflammatory and neurodegenerative disorders, has given rise to ...
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Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (2008)Cu(2+) ions and and GSH molecules interact swiftly to form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing ...
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Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-07-01)Cu2+ ions and GSH molecules interact to swiftly form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing Cu(I)– ...
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Aliaga, Margarita E.; Carrasco Pozo, Catalina; López Alarcón, Camilo; Speisky Cosoy, Hernán (Springer, 2010)Cu2? ions and reduced glutathione (GSH) swiftly interact to form the physiologically occurring Cu(I)–[GSH]2 complex. Prompted by the recently reported ability of this complex to generate superoxide radicals from molecular ...
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Andriamihaja, Mireille; Lan, Annaïg; Beaumont, Martin; Audebert, Marc; Wong, Ximena; Yamada, Kana; Yin, Yulong; Tomé, Daniel; Carrasco Pozo, Catalina; Gotteland, Martín; Kong, Xiangfeng; Blachier, François (Elsevier, 2015)p-Cresol that is produced by the intestinal microbiota horn the amino acid tyrosine is found at millimolar concentrations in the human feces. The effects of this metabolite On colonic epithelial cells were tested in this ...
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Carrasco Pozo, Catalina; Mizgier, María Luisa; Speisky Cosoy, Hernán; Gotteland, Martín (Elsevier, 2012)The beneficial effects of dietary polyphenols on health are due not only to their antioxidant properties but also to their antibacterial, anti-inflammatory and/or anti-tumoral activities. It has recently been proposed that ...
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Carrasco Pozo, Catalina; Aliaga, Margarita E.; Olea Azar, Claudio; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER, 2008-11-15)The present study investigated the redox-consequences of the interaction between various endogenous thiols (RSH)-glutathione, cysteine, homocysteine, c-glutamyl-cysteine, and cysteinyl-glycine-and Cu2+ ions, in terms of ...
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Tan, Kah Ni; Hood, Rebecca; Warren, Kirby; Pepperall, Debbie; Carrasco Pozo, Catalina; Manzanero, Silvia; Borges, Karin; Spratt, Neil J. (Elsevier Ireland Ltd, 2018)© 2018 Elsevier B.V. Triheptanoin, the medium-chain triglyceride of heptanoate, has been shown to be anticonvulsant and neuroprotective in several neurological disorders. In the gastrointestinal tract, triheptanoin is ...
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Carrasco Pozo, Catalina; Álvarez Lueje, Alejandro; Olea Azar, Claudio; López Alarcón, Camilo; Speisky Cosoy, Hernán (SOC EXPERIMENTAL BIOLOGY MEDICINE, 2006-10)Homocysteine (Hcys) has been implicated in various oxidative stress–related disorders. The presence of a thiol on its structure allows Hcys to exert a double-edge redox action. Depending on whether Cu2þions occur ...
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Vergara, Daniela; Ávila, Daniela; Escobar, Elizabeth; Carrasco Pozo, Catalina; Sánchez Córdova, Andrés; Gotteland Russell, Martín (BioMed Central, 2015)Background: Respiratory diseases are associated with pulmonary oxidative stress and inflammatory processes. Though studies in animal models suggest that dietary polyphenols improve lung injury, no intervention studies were ...
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Carrasco Pozo, Catalina; Castillo, Rodrigo L.; Beltrán Muñoz, Caroll; Miranda, Alfonso; Fuentes, Jocelyn; Gotteland, Martín (Elsevier, 2016)The aim of this study was to determine the gastrointestinal protection by quercetin against indomethacin-induced oxidative stress and inflammation, with specific interest in studying the underlying molecular mechanisms. ...
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Carrasco Pozo, Catalina; Castillo, Rodrigo L.; Beltrán, Caroll; Miranda, Alfonso; Fuentes, Jocelyn; Gotteland, Martin (Elsevier Inc., 2016)© 2015 Elsevier Inc.The aim of this study was to determine the gastrointestinal protection by quercetin against indomethacin-induced oxidative stress and inflammation, with specific interest in studying the underlying ...
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Rodríguez Borges, Jorge; Arán, Vicente J.; Boiani, Lucía; Olea Azar, Claudio; Lavaggi, María Laura; González, Mercedes; Cerecetto, Hugo; Diego Maya, Juan; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2009-12-15)New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific ...
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Herrera Videla, Emilio; Farías, Jorge; González Candia, Alejandro; Short, Stefania; Carrasco Pozo, Catalina; Castillo Peñaloza, Rodrigo (MDPI, 2015)Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing ...
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Farías, Jorge; Herrera Videla, Emilio; Carrasco Pozo, Catalina; Sotomayor Zárate, Ramón; Cruz, Gonzalo; Morales Retamales, Paola; Castillo Peñaloza, Rodrigo (Pergamon-Elsevier, 2016)Hypoxia is the failure of oxygenation at the tissue level,where the reduced oxygen delivered is not enough to satisfy tissue demands. Metabolic depression is the physiological adaptation associated with reduced oxygen ...
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Carrasco Pozo, Catalina; Morales, Pamela; Gotteland, Martin (2013)The aim of this study was to determine the protective effect of quercetin, epigallocatechingallate, resveratrol, and rutin against the disruption of epithelial integrity induced by indomethacin in Caco-2 cell monolayers. ...