Browsing by Author "Couve Correa, Andrés"
Now showing items 1-12 of 12
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(National Academy of Sciences, 2016)The regulation of the axonal proteome is key to generate and maintain neural function. Fast and slow axoplasmic waves have been known for decades, but alternative mechanisms to control the abundance of axonal proteins based ...
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(2009)Background: Marlin-1 is a microtubule binding protein that associates specifically with the GABAB1 subunit in neurons and with members of the Janus kinase family in lymphoid cells. In addition, it binds the molecular motor ...
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Converging pathways in the occurrence of endoplasmic reticulum (er) stress in Huntington's disease (2011)A variety of neurological diseases including Huntington's disease (HD), Alzheimer's disease and Parkinson's disease share common neuropathology, primarily featuring the presence of abnormal protein inclusions containing ...
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(Universidad de Chile, 2018)
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(Universidad de Chile, 2017)El gen klotho fue descrito a finales del siglo pasado como el “gen del envejecimiento”, pues su ausencia gatillaba en ratones un fenotipo de progeria y su sobre-expresión extendía la expectativa de vida hasta en un 30,8%. ...
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(BioMed Central Ltd., 2016)© 2016 Mardones et al. Background: In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt ...
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(2007)The cytoskeleton and cytoskeletal motors play a fundamental role in neurotransmitter receptor trafficking, but proteins that link GABAB receptors (GABABRs) to the cytoskeleton have not been described. We recently identified ...
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(Universidad de Chile, 2014)Las neuronas son células del sistema nervioso que están altamente diferenciadas y morfológicamente polarizadas en dominios axonales y somatodendríticos, características que sustentan sus funciones. Tanto el establecimiento ...
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(Wiley-VCH Verlag, 2014)The efficient folding of membrane and secreted proteins relies on the unfolded protein response (UPR) to buffer fluctuations in the load of misfolded proteins. Although the UPR is thought to operate on a generic manner ...
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(2012)The formation of the nervous systems requires processes that coordinate proliferation, differentiation and migration of neuronal cells, which extend axons, generate dendritic branching and establish synaptic connections ...
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(Universidad de Chile, 2015)La población mundial envejece en forma acelerada. Considerando que el deterioro cognitivo es uno de los principales determinantes de enfermedad y discapacidad de los adultos mayores, la comprensión de sus mecanismos f ...
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(Company of Biologists Ltd, 2014)In neurons, secretory organelles within the cell body are complemented by the dendritic endoplasmic reticulum (ER) and Golgi outposts (GOPs), whose role in neurotransmitter receptor trafficking is poorly understood. ...
