Now showing items 1-7 of 7

    • Lisbona Pizarro, María Fernanda (Universidad de Chile, 2009)
      The endoplasmic reticulum (ER) is an essential organelle for protein folding and secretion. Different conditions alter its functioning promoting the accumulation of misfolded proteins at its lumen, a condition referred ...
    • Sepulveda Durand, Martín Nicolás (Universidad de Chile, 2015)
      El estrés celu¡ar asociado a la acumulación de proteínas mal plegadas en el retículo endoplásmico (RE) es una de las características patológicas principales de la enfermedad neurodegénerat¡va esclerosis lateral amiotrofica ...
    • Li, Yiran E.; Sowers, James R.; Hetz Flores, Claudio Andrés; Ren, Jun (Nature, 2022)
      The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular organelles with vital roles in the regulation of cell signaling and function. While the ER participates in a number of biological processes ...
    • Pihan, Philippe; Lisbona, Fernanda; Borgonovo, Janina Edith; Edwards Jorquera, Sandra Sofía; Nunes Hasler, Paula; Castillo, Karen; Kepp, Oliver; Urra, Hery; Saarnio, Suvi; Vihinen, Helena; Carreras Sureda, Amado; Forveille, Sabrina; Sauvat, Allan; De Giorgis, Daniela; Pupo, Amaury; Rodríguez, Diego A.; Quarato, Giovanni; Sagredo, Alfredo; Lourido Araneda, María Fernanda; Letai, Anthony; Latorre, Ramón; Kroemer, Guido; Demaurex, Nicolás; Jokitalo, Eija; Concha Nordemann, Miguel Luis Angel; Glavic Maurer, Alvaro Alberto; Green, Douglas R.; Hetz Flores, Claudio Andrés (Amer Assoc Advancement Science, 2021)
      Programmed cell death is regulated by the balance between activating and inhibitory signals. Here, we have identified RECS1 (responsive to centrifugal force and shear stress 1) [also known as TMBIM1 (transmembrane BAX ...
    • Mercado, Gabriela; Castillo Jorquera, Valentina Andrea; Vidal, René; Hetz Flores, Claudio Andrés (Frontiers Media, 2015)
    • Rozas Rojas, Pablo Sebastián; Pinto, Cristina; Martínez Traub, Francisca José; Díaz Hinojosa, Rodrigo Ignacio; Pérez, Viviana; Becerra, Daniela; Ojeda, Patricia; Ojeda, Jorge; Wright, Madison T.; Mella, Jéssica; Plate, Lars; Henríquez, Juan Pablo; Hetz Flores, Claudio Andrés; Bilches Medinas, Danilo (BMC, 2021)
      Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice ...
    • Troncoso Escudero, Paulina Beatriz; Hetz Flores, Claudio Andrés; Vidal, René L. (Wolters Kluwer Medknow, 2021)