Browsing by Author "Paula Lima, Andrea"
Now showing items 1-15 of 15
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(MARY ANN LIEBERT INC, 2011-04)Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A beta Os at ...
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(Frontiers Research Foundation, 2013-07-30)
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(2011)Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function. Here, we report that AβOs at sublethal concentrations ...
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(Hindawi Limited, 2016)© 2016 Pedro Lobos et al.Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer's disease pathology. We reported previously that amyloid-β peptide oligomers (AβOs) produce ...
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(2013)Alzheimer′s disease (AD) is the most common form of dementia in the elderly. Memory loss in AD is increasingly attributed to soluble oligomers of the amyloid-b peptide (AbOs), toxins that accumulate in AD brains and ...
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(Universidad de Chile, 2023)La enfermedad de Alzheimer (EA) es la causa más común de demencia en personas mayores y se caracteriza por la formación de placas seniles extracelulares formadas por cúmulos del péptido de β-amiloide (Aβ) y ovillos ...
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(Universidad Costa Rica, Facultad Odontología, 2022)Periodontitis is a low-grade inflammatory disease caused by a subgingival dysbiotic microbiota. Multiple studies have determined the higher prevalence of tooth loss and poor oral hygiene in patients with Alzheimer's disease ...
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(NATL ACAD SCIENCES, 2011-02-15)Ryanodine receptors (RyR)amplify activity-dependent calciuminflux via calcium-induced calcium release. Calcium signals trigger postsynaptic pathways in hippocampal neurons that underlie synaptic plasticity, learning, ...
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(Universidad de Chile, 2015)La enfermedad de Alzheimer (EA) es un desorden neurodegenerativo caracterizado por la pérdida progresiva de memoria. Los oligómeros solubles sinaptotóxicos del péptido β-amiloide (AβOs) son reconocidos como los agentes ...
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(2014)Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
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(Frontiers Research Foundation, 2017)© 2017 SanMartín, Veloso, Adasme, Lobos, Bruna, Galaz, García, Hartel, Hidalgo and Paula-Lima. Amyloid β peptide oligomers (AβOs), toxic aggregates with pivotal roles in Alzheimer’s disease, trigger persistent and low ...
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(2018)El estrés oxidativo y la desregulación de la señalización de calcio son señales importantes en una variedad de enfermedades neurodegenerativas, incluyendo la enfermedad de Alzheimer (EA). El factor de transcripción STAT3 ...
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(2012)Two major lesions are pathological hallmarks in Alzheimer's disease (AD): the presence of neurofibrillary tangles formed by intracellular aggregates of the hyperphosphorylated form of the cytoskeletal tau protein, and of ...
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(Elsevier B.V., 2018)© 2018 Elsevier Inc. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include ...
