Browsing by Author "Ronco Macchiavello, Ana María"
Now showing items 1-20 of 24
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Ronco Macchiavello, Ana María; Llanos Silva, Miguel; Tamayo, Daniela; Hirsch Birn, Sandra (2007)Background and aims: Several studies have shown the beneficial effects of folate treatment in improving cardiovascular function. However, the mechanisms involved have not been clearly identified. The aim of this study is ...
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Moraga,; Llanos Silva, Miguel; Ronco Macchiavello, Ana María (BioScientifica Ltd., 1997)In this work, the involvement of arachidonic acid (AA) in the luteinizing hormone and human chorionic gonadotrophin (LH/hCG) action on Leydig cells was studied. Experiments were first designed to evaluate [14C]AA incorporation ...
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Ronco Macchiavello, Ana María; Moraga,; Llanos Silva, Miguel (2002)We have previously demonstrated that the release of arachidonic acid (AA) from human chorionic gonadotropin (hCG)-stimulated Leydig cells occurs in a dose- and time-dependent manner. In addition, the amount of AA released ...
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Ronco Macchiavello, Ana María; Urrutia,; Montenegro,; Llanos, Adolfo (2009)Cadmium exposure induces low birth weight through unknown mechanisms. Since low birth weight is associated to foetal exposure to high glucocorticoids (GC) concentrations, we hypothesized that low birth weight induced by ...
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Zepeda Iriarte, Ramiro; Castillo, Paula; Sáez, Daniel; Llanos Silva, Miguel; Ronco Macchiavello, Ana María (Springer, 2012)It has been suggested that prenatal exposure to cadmium may alter the cardiovascular function during adulthood. Using the left coronary artery ligation model of acute myocardial infarction, we studied the cardiac ...
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Morcillo Bastidas, Maira Alejandra (Universidad de Chile, 2020-04)En Colombia la fortificación de harinas con AF se implementó desde 1994 para disminuir los DTN. Sin embargo, a la fecha no hay reportes del impacto que dicha estrategia sobre la ingesta de folatos en la población. ...
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Llaguno Maturana, Emanuel (Universidad de Chile., 2010)EI cadmio es un contaminante con eonocidos efectos carcinogenicos y "disruptores endocrinos". Nosotros demostramos previamente que la exposicion prenatal a cadmio puede inducir bajo peso al naeer, 10 que esta asociado a ...
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Ronco Macchiavello, Ana María; Llaguno, Emanuel; Epuñán, María José; Llanos Silva, Miguel (PERGAMON-ELSEVIER SCIENCE LTD, 2010-09)Cadmium is a toxicant with known carcinogenic and endocrine disruptor effects. We have previously reported that prenatal exposure to cadmium may induce low birth weight which is associated to increased foetal exposure ...
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Montenegro Herrera, Marcela (Universidad de Chile, 2009)Una alteración del ambiente materno durante la gestación puede originar una readecuación fisiológica en el feto llamada “reprogramación fetal” (RF), con consecuencias funcionales adversas a largo plazo. La exposición ...
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Rodríguez, Juan M.; Miranda, Dante; Bunout Barnett, Daniel; Ronco Macchiavello, Ana María; Maza Cave, María Pía de la; Hirsch Birn, Sandra (ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2015)Folic acid (FA) consumption at high levels has been associated with colon cancer risk. Several mechanisms have been proposed to explain this association. The Notch signal pathway has been implicated in the regulation of ...
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Castaño, Erika; Piñuñuri, Raúl; Hirsch Birn, Sandra; Ronco Macchiavello, Ana María (Sociedad Chilena de Pediatría, 2017)El aporte de folatos durante el embarazo es esencial para un desarrollo fetal y placentario adecuados y para la salud del individuo a largo plazo. Su deficiencia puede inducir alteraciones y patologías fetales como bajo ...
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Peñailillo, Reyna; Guajardo, Angélica; Llanos Silva, Miguel; Hirsch Birn, Sandra; Ronco Macchiavello, Ana María (Public Library Science, 2015)In the placenta, 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) limits fetal glucocorticoid exposure and its inhibition has been associated to low birth weight. Its expression, encoded by the HSD11B2 gene is ...
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Peñailillo, Reyna; Guajardo, Angélica; Llanos Silva, Miguel; Hirsch Birn, Sandra; Ronco Macchiavello, Ana María (Public Library of Science, 2015)In the placenta, 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) limits fetal glucocorticoid exposure and its inhibition has been associated to low birth weight. Its expression, encoded by the HSD11B2 gene is regulated ...
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Ronco Macchiavello, Ana María; Argüello, Graciela; Suazo Romo, Miriam; Llanos Silva, Miguel (ELSEVIER SCI IRELAND LTD, 2005-03-01)Experiments were designed to evaluate and compare metallothionein (NIT), zinc and cadmium levels in human placentas of smoking and non-smoking women. Smoking was assessed by self-reported cigarette consumption and urine ...
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Hirsch Birn, Sandra; Ronco Macchiavello, Ana María; Pinardi, Guido; Montequin, María José; Leiva Balich, Laura; Llanos Silva, Miguel; Maza Cave, María Pía de la; Bunout Barnett, Daniel (2007)
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Hirsch Birn, Sandra; Ronco Macchiavello, Ana María; Pinardi Testa, Gianni; Montequin, María José; Leiva Balich, Laura; Maza Cave, María Pía de la; Llanos Silva, Miguel; Bunout Barnett, Daniel (CHURCHILL LIVINGSTONE, 2008-12)Background: Endothelial dysfunction is a key process in atherosclerosis. Hypomethylation is one of the postulated mechanisms involved in atherogenesis and is mainly secondary to a decrease in essential factors such as, ...
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Ronco Macchiavello, Ana María; Montenegro, Marcela; Castillo, Paula; Urrutia, Manuel; Sáez, Daniel; Hirsch Birn, Sandra; Zepeda Iriarte, Ramiro; Llanos Silva, Miguel (Elsevier, 2011)Several cardiovascular diseases (CVD) observed in adulthood have been associated with environmental influences during fetal growth. Here, we show that maternal exposure to cadmium, a ubiquitously distributed heavy metal ...
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Castaño Moreno, Erika; Ronco Macchiavello, Ana María; Casanello, Paola (Springer, 2023)Fetal growth and development are influenced by maternal nutrition and gestational weight gain. Adequate intake of nutrients such as folate, vitamin B12, and docosahexaenoic acid (DHA) is essential for healthy fetal and ...
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Hirsch Birn, Sandra; Ronco Macchiavello, Ana María; Guerrero Bosagna, Carlos; Maza Cave, María Pía de la; Leiva Balich, Laura; Barrera Acevedo, María; Llanos Silva, Miguel; Alliende Rodríguez, María Angélica; Silva, Francisca; Bunout Barnett, Daniel (ELSEVIER, 2008-12)Objective: We assessed the impact of high serum folate concentration oil erythrocyte S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) concentrations, SAM/SAH ratio, CpG methylation levels across the promoter region ...
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Hirsch Birn, Sandra; Miranda, Dante; Muñoz, Estefanía; Montoya, Margarita; Ronco Macchiavello, Ana María; Maza Cave, María Pía de la; Bunout Barnett, Daniel (Elsevier, 2013)Objectives: Folate supplementation may be associated with an increased risk of developing several types of cancer and a derangement of immune function.Among the latter, Natural killer (NK) cells are involved in ...