Browsing by Author "Saavedra Saavedra, Iván"
Now showing items 1-17 of 17
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(1991)The correct clinical use of drug plasma levels is frequently jeopardized by neglecting to consider pharmacokinetic parameters at the time of sample drawing. A form to be filled at this time revealed that inadequate information ...
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(Universidad de Chile, 2015)La importancia mundial que hoy tienen las plantas medicinales ha fomentado el desarrollo de fitofármacos por las compañías farmacéuticas. A diferencia de los fármacos sintéticos, las etapas para el desarrollo de fitofármacos ...
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(1990)We studied the distribution of the acetylator phenotype in 47 patients aged 15 to 77 years receiving isonyazid as antituberculous therapy. 62% were fast and 32% slow acetylators. Ethnical, socio-economic and biologic factors ...
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(2003)Objectives: To assess the relative bioavailability of two oral formulations of ambroxol commercialized in Chile, a generic syrup and the original product, Mucosolvan R from Boehringer Ingelheim. Methods: A randomized, ...
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(1990)The bioavailability of carbamazepine from 4 commercially available products was evaluated in 12 healthy volunteers. A crossover design was used and each patients received 400 mg of each product. Plasma levels of the drug ...
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(Universidad de Chile, 2008)El presente trabajo ha sido orientado al estudio y formulación de un protocolo para la determinación de los niveles plasmáticos de ácido micofenólico en pacientes pediátricos trasplantados renales. La cuantificación del ...
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(1992)A simple specific and sensitive high pressure liquid chromatography method (HPLC) to measure amiodarone and desethylamiodarone is described. The plasma sample is deproteinized with acetonitrile and a 50 ul aliquote run in ...
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(1977)In 40 unanaesthetized, curarized cats, the reciprocal electrophysiological relationship between the caudate nucleus and the Pul-LP complex was analyzed. With pulses I/sec applied to the pulvinar nucleus, evoked responses ...
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(1992)Since april 1957 to april 1986, the Gynecologic Oncologic Unit of San Juan de Dios Hospital, Santiago, registered 255 cases of endometrial carcinoma. 48 cases where clinically etapified because of no previous pelviabdominal ...
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(2012)Cancer is a leading cause of death worldwide. The cancer incidence rate in Chile is 133.7/100,000 inhabitants and it is the second cause of death, after cardiovascular diseases. Most of the antineoplastic drugs are ...
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(1996)Chronic toluene inhalation provokes significant deleterious neurological effects in young glue sniffers and exposed workers. We have developed a chronic toluene inhalation model in the cat to address this issue. Neuronal ...
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(1991)The effect of a prolonged course of oral acyclovir was evaluated in 55 pts with recurrent genital herpes (36 men and 19 women). The pts were voluntarily enrolled after an acute episode, with tissue culture viral isolation. ...
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(1990)We evaluated pharmacokinetic parameters and bioavailability of 4 sustained release theophylline preparations. A crossover design was used in 12 healthy males aged 22 to 27 years old. Each individual received 250 mg iv ...
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(1991)In twenty two adult cats, distributed in four groups, stainless steel electrodes were implanted in the superior colliculus and the substantia nigra of both sides in order: 1) to find the current intensity threshold values ...
