Browsing by Author "Solari, Sandra"

Now showing items 1-4 of 4

    • Identification of novel 11b-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristóbal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia Castillo, Alejandra; Baudrand, René; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A.; Fardella, Carlos E. (Elsevier, 2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11b-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Performance of SARS-CoV-2 rapid antigen test compared with real-time RT-PCR in asymptomatic individuals 
      Peña, Mónica; Ampuero Martínez, Manuel Andrés; Garcés, Carlos; Gaggero Brillouet, Aldo Andres; García, Patricia; Velásquez, María Soledad; Luza, Ricardo; Álvarez, Pía; Paredes, Fabio; Acevedo, Johanna; Farfán Urzúa, Mauricio Javier; Solari, Sandra; Soto Rifo, Ricardo Andrés; Valiente Echeverría, Fernando Andrés (Elsevier, 2021)
      Screening, testing and contact tracing plays a pivotal role in control of the COVID-19 pandemic. To enable this it is necessary to increase the testing capacity. This study compared a SARS-CoV-2 rapid antigen test (RAT) ...
    • Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population 
      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Vecchiola, Andrea; Allende, Fidel; Solari, Sandra; García Nannig, Lorena; Lavandero González, Sergio; Valdivia, Carolina; Fuentes, Cristobal; Lagos, Carlos F.; Martínez Aguayo, Alejandro; Baudrand, René; Aglony, Marlene; García, Hernán; Fardella, Carlos E. (Oxford University Press, 2014)
      The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) ...
    • Screening of COVID-19 cases through a Bayesian network symptoms model and psychophysical olfactory test 
      Eyheramendy, Susana; Saa, Pedro A.; Undurraga, Eduardo A.; Valencia, Carlos; López, Carolina; Méndez, Luis; Pizarro Berdichevsky, Javier Alejandro; Finkelstein Kulka, Andrés; Solari, Sandra; Salas, Nicolás; Bahamondes, Pedro; Ugarte, Martín; Barceló, Pablo; Arenas, Marcelo; Agosín, Eduardo (Cell, 2021)
      The sudden loss of smell is among the earliest and most prevalent symptoms of COVID-19 when measured with a clinical psychophysical test. Research has shown the potential impact of frequent screening for olfactory ...