Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population
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Polymorphisms-in-the-RAC1-Gene-Are-Associated-With-Hypertension-Risk-Factors-in-a-Chilean-Pediatric-Population.pdf (2.149Mb)Publication date
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Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population
Abstract
The GTPase Rac1 has been implicated in hypertension as a modulator
of mineralocorticoid receptor activity. Our aim is to investigate the
frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478
(intron 3, T>C) in the RAC1 gene and perform association studies with
clinical and biochemical parameters in a Chilean pediatric cohort.
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Artículo de publicación ISI
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This work
was supported by Chilean grants from Fondo Nacional de
Desarrollo Científico y Tecnológico (FONDECYT) 1130427,
a b
c d
P = 0.03
P = 0.04
P = 0.004 P = 0.007
Figure 2. Genotype distribution and biochemical associations of the polymorphisms rs10951982 and rs836478 of the RAC1 gene in normotensive subjects
with hypertensive parents (NH) and normotensive subjects with normotensive parents (NN) (P <0.05). (a) Results obtained for single nucleotide polymorphism
(SNP) rs10951982 located in intron 1. The group of children with GA/AA genotype had lower diastolic blood pressure (DBP) index compared with
subjects with GG genotype. (b, c, and d) Results obtained for SNP rs836478 located in intron 3, using the Kruskal–Wallis and Dunn’s test (P < 0.05). (b) The
group of NN children with TT genotype had higher plasminogen activator inhibitor-1 levels compared with subjects with TC/CC genotype. The group of NH
children with TT genotype had (c) higher metalloproteinase-9 levels and (d) lower interleukin 6 (IL-6) levels compared with subjects with TC/CC genotype.
Downloaded from http://ajh.oxfordjournals.org/ at Universidad de Chile on October 8, 2014
American Journal of Hypertension 27(3) March 2014 307
Polymorphisms in RAC1 and Hypertension Risk Factors
FONDEF IDeA CA12i10150, and Millennium Institute of
Immunology and Immunotherapy (MIII) P09/016-F (ICM).
C.A.C. and C.F.L. are fellows of the Comisión Nacional de
Investigación Científica y Tecnológica de Chile (CONICYT).
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URI: https://repositorio.uchile.cl/handle/2250/121866
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American Journal of Hypertension 27(3) March 2014
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