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Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric population

Authordc.contributor.authorTapia Castillo, Alejandra 
Authordc.contributor.authorCarvajal, Cristian A. es_CL
Authordc.contributor.authorCampino, Carmen es_CL
Authordc.contributor.authorVecchiola, Andrea es_CL
Authordc.contributor.authorAllende, Fidel es_CL
Authordc.contributor.authorSolari, Sandra es_CL
Authordc.contributor.authorGarcía Nannig, Lorena es_CL
Authordc.contributor.authorLavandero González, Sergioes_CL
Authordc.contributor.authorValdivia, Carolina es_CL
Authordc.contributor.authorFuentes, Cristobal es_CL
Authordc.contributor.authorLagos, Carlos F. es_CL
Authordc.contributor.authorMartínez Aguayo, Alejandro es_CL
Authordc.contributor.authorBaudrand, René es_CL
Authordc.contributor.authorAglony, Marlene es_CL
Authordc.contributor.authorGarcía, Hernán es_CL
Authordc.contributor.authorFardella, Carlos E. es_CL
Admission datedc.date.accessioned2014-10-14T19:38:21Z
Available datedc.date.available2014-10-14T19:38:21Z
Publication datedc.date.issued2014
Cita de ítemdc.identifier.citationAmerican Journal of Hypertension 27(3) March 2014en_US
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/121866
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractThe GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters in a Chilean pediatric cohort.en_US
Patrocinadordc.description.sponsorshipThis work was supported by Chilean grants from Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) 1130427, a b c d P = 0.03 P = 0.04 P = 0.004 P = 0.007 Figure 2. Genotype distribution and biochemical associations of the polymorphisms rs10951982 and rs836478 of the RAC1 gene in normotensive subjects with hypertensive parents (NH) and normotensive subjects with normotensive parents (NN) (P <0.05). (a) Results obtained for single nucleotide polymorphism (SNP) rs10951982 located in intron 1. The group of children with GA/AA genotype had lower diastolic blood pressure (DBP) index compared with subjects with GG genotype. (b, c, and d) Results obtained for SNP rs836478 located in intron 3, using the Kruskal–Wallis and Dunn’s test (P < 0.05). (b) The group of NN children with TT genotype had higher plasminogen activator inhibitor-1 levels compared with subjects with TC/CC genotype. The group of NH children with TT genotype had (c) higher metalloproteinase-9 levels and (d) lower interleukin 6 (IL-6) levels compared with subjects with TC/CC genotype. Downloaded from http://ajh.oxfordjournals.org/ at Universidad de Chile on October 8, 2014 American Journal of Hypertension 27(3) March 2014 307 Polymorphisms in RAC1 and Hypertension Risk Factors FONDEF IDeA CA12i10150, and Millennium Institute of Immunology and Immunotherapy (MIII) P09/016-F (ICM). C.A.C. and C.F.L. are fellows of the Comisión Nacional de Investigación Científica y Tecnológica de Chile (CONICYT).en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherOxford University Pressen_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectBlood pressureen_US
Títulodc.titlePolymorphisms in the RAC1 gene are associated with hypertension risk factors in a chilean pediatric populationen_US
Document typedc.typeArtículo de revista


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