Browsing by Author "Zapata Torres, Gerald"
Now showing items 1-20 of 25
-
(John Wiley and Sons Inc., 1999)The effect of the basicity of methyl-amines on hydrogen bonding (HB) with HCOOH is examined in both gas and solution phases. In the gas phase, the strength of HB may be related to the proton affinity (PA) difference between ...
-
(Universidad de Chile, 2019)Varios estudios relacionados con el tratamiento de enfermedades neurodegenerativas (EN) han mostrado que moléculas inhibidoras de Monoamino Oxidasas (iMAO) disminuyen los efectos asociados a éstas, entre ellos se encuentra ...
-
(Universidad de Chile, 2016)En esta tesis se estudió la complejación de los ligandos 6-([1,2,3]Triazolo[1,5-a]piridin-3-il)piridin-2-il)piridin-2-il)metanona (TPPM) y 3-(1H-benzimidazol-2-il)-7-(dietilamino) cromen-2-ona (C7) con 2,6 dimetil-β-ciclodextrina ...
-
(2012)In order to develop future therapeutic applications for cell penetrating peptides (CPPs), it is essential to characterize their internalization mechanisms, as they might affect the stability and the accessibility of the ...
-
(Universidad de Chile, 2016)En esta tesis se estudiaron tanto las características fisicoquímicas de los complejos de inclusión de derivados de ariloxazinonas y arilnaftoxazoles en ciclodextrinas y se determinaron los parámetros termodinámicos que ...
-
(Sociedad Chilena de Quimica, 2004)Condensation of 4-methylthiobenzaldehyde with 1-nitropropane unexpectedly afforded separable amounts of both (E)- and (Z)-1-(4-methylthiophenyl)-2- nitrobutene. The 1H and 13C NMR spectra allowed the unequivocal assignment ...
-
(2012)Although substrate conversion mediated by human monoaminooxidase (hMAO) has been associated with the deprotonated state of their amine moiety, data regarding the influence of protonation on substrate binding at the active ...
-
(Blackwell Publishing Inc., 2018)© 2018 The American Society of Photobiology Naphthoxazole derivatives are small heterocyclic compounds endowed with outstanding fluorescence properties. In this work, we report a detailed study of the intense white light ...
-
(Elsevier, 2001)The electronic structures of one-dimensional metallomacrocycles with bidentate bridging ligands, such as -[MacM(L)]n (Mac = phthalocyaninato dianion, tetrabenzoporphyrinato dianion; M = Fe(II), Ru(II), Os(II); L = dabco, ...
-
(American Society for Pharmacology and Experimental Therapy, 2010)The Erythrina alkaloids erysodine and dihydro-β-erythroidine (DHβE) are potent and selective competitive inhibitors of α4β2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...
-
(Blackwell Publishing Ltd, 2019)(R/S)-Salsolinol is a full agonist of the μ-opioid receptor (μOR) Gi protein pathway via its (S)-enantiomer and is functionally selective as it does not promote β-arrestin recruitment. Compared to (S)-salsolinol, the ...
-
(2009)This study reports the comparative molecular modeling, docking and dynamic simulations of human α9α10 nicotinic acetylcholine receptors complexed with acetylcholine, nicotine and α-conotoxin RgIA, using as templates the ...
-
(1997)The monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives with different substituents at or around the para position of the aromatic ring were evaluated. In in vitro studies in which a crude ...
-
(Elsevier, 2014)Rationale: Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca2+ channels and their renowned antioxidant properties. Methods: We synthesized six novel ...
-
(2011)Airway inflammation is a common condition where glucocorticoids (GC) are a well-established therapy. It has been demonstrated that GC stimulate components of innate immunity. Specifically, GC up-regulate TLR2 expression ...
-
(2004)The hydride transfer process between the isoalloxazine moiety of flavins and the nicotinamide moiety of NAD(P)H has been explored by using density functional theory based reactivity index in the 1-methylnicotinamide-lumiflavine ...
-
(Frontiers Media S.A., 2017)© 2017 Berríos-Cárcamo, Quintanilla, Herrera-Marschitz, Vasiliou, Zapata-Torres and Rivera-Meza. Background: Several studies have shown that the ethanol-derived metabolite salsolinol (SAL) can activate the mesolimbic system, ...
-
(Universidad de Chile, 2021)El CO2 es sin lugar a duda una preocupación en el contexto de la química ambiental, por su contribución al calentamiento global y por su carácter inerte. Los esfuerzos se centran en la búsqueda de formas para su reutilización ...
-
(2013)Diels-Alder cycloaddition of 8,8-dimethylnaphthalene-1,4,5(8H)-trione with diastereomeric hydroxysulfinyldienes proceeded with high yields and good π-facial and regioselectivities. The hydroxysulfoxide moiety controls the ...
-
(Universidad de Chile, 2019)Se sintetizó una familia de derivados de triptamina y unos pocos análogos de 5- metoxitriptamina con sustituciones diferentes en el bencilo y se realizaron ensayos in vitro de afinidad y actividad funcional para los ...
